Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that hep...

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Autores principales: Ghezzi, Silvia, Cooper, Lynsay, Rubio, Alicia, Pagani, Isabel, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Pelletier, Julien, Meneghetti, Maria Cecilia Z., Lima, Marcelo A., Skidmore, Mark A., Broccoli, Vania, Yates, Edwin A., Vicenzi, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113768/
https://www.ncbi.nlm.nih.gov/pubmed/28063994
http://dx.doi.org/10.1016/j.antiviral.2016.12.023
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author Ghezzi, Silvia
Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Broccoli, Vania
Yates, Edwin A.
Vicenzi, Elisa
author_facet Ghezzi, Silvia
Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Broccoli, Vania
Yates, Edwin A.
Vicenzi, Elisa
author_sort Ghezzi, Silvia
collection PubMed
description The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).
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spelling pubmed-71137682020-04-02 Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells Ghezzi, Silvia Cooper, Lynsay Rubio, Alicia Pagani, Isabel Capobianchi, Maria Rosaria Ippolito, Giuseppe Pelletier, Julien Meneghetti, Maria Cecilia Z. Lima, Marcelo A. Skidmore, Mark A. Broccoli, Vania Yates, Edwin A. Vicenzi, Elisa Antiviral Res Article The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). Elsevier B.V. 2017-04 2017-01-05 /pmc/articles/PMC7113768/ /pubmed/28063994 http://dx.doi.org/10.1016/j.antiviral.2016.12.023 Text en © 2017 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ghezzi, Silvia
Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Broccoli, Vania
Yates, Edwin A.
Vicenzi, Elisa
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_full Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_fullStr Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_full_unstemmed Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_short Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
title_sort heparin prevents zika virus induced-cytopathic effects in human neural progenitor cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113768/
https://www.ncbi.nlm.nih.gov/pubmed/28063994
http://dx.doi.org/10.1016/j.antiviral.2016.12.023
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