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Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral str...

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Detalles Bibliográficos
Autores principales:	Noble, Christian G., Li, Shi-Hua, Dong, Hongping, Chew, Sock Hui, Shi, Pei-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2014
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113791/ https://www.ncbi.nlm.nih.gov/pubmed/25241250 http://dx.doi.org/10.1016/j.antiviral.2014.09.003

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