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Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells

BACKGROUND AND PURPOSE: Celastrol, a quinone methide triterpene isolated from the root extracts of Tripterygium wilfordii, can greatly induce the gene expression activity of heme oxygenase-1 (HO-1) to achieve disease prevention and control. HO-1 induction was recently shown to result in anti-HCV act...

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Detalles Bibliográficos
Autores principales:	Tseng, Chin-Kai, Hsu, Sung-Po, Lin, Chun-Kuang, Wu, Yu-Hsuan, Lee, Jin-Ching, Young, Kung-Chia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113881/ https://www.ncbi.nlm.nih.gov/pubmed/28935193 http://dx.doi.org/10.1016/j.antiviral.2017.09.010

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