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Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry

This review focuses on the recent progress in our understanding of filovirus protein structure/function and its impact on antiviral research. Here we focus on the surface glycoprotein GP(1,2) and its different roles in filovirus entry. We first describe the latest advances on the characterization of...

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Detalles Bibliográficos
Autores principales: Martin, Baptiste, Hoenen, Thomas, Canard, Bruno, Decroly, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113884/
https://www.ncbi.nlm.nih.gov/pubmed/27640102
http://dx.doi.org/10.1016/j.antiviral.2016.09.001
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author Martin, Baptiste
Hoenen, Thomas
Canard, Bruno
Decroly, Etienne
author_facet Martin, Baptiste
Hoenen, Thomas
Canard, Bruno
Decroly, Etienne
author_sort Martin, Baptiste
collection PubMed
description This review focuses on the recent progress in our understanding of filovirus protein structure/function and its impact on antiviral research. Here we focus on the surface glycoprotein GP(1,2) and its different roles in filovirus entry. We first describe the latest advances on the characterization of GP gene-overlapping proteins sGP, ssGP and Δ-peptide. Then, we compare filovirus surface GP(1,2) proteins in terms of structure, synthesis and function. As they bear potential in drug-design, the discovery of small organic compounds inhibiting filovirus entry is a currently very active field. Although it is at an early stage, the development of antiviral drugs against Ebola and Marburg virus entry might prove essential to reduce outbreak-associated fatality rates through post-exposure treatment of both suspected and confirmed cases.
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spelling pubmed-71138842020-04-02 Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry Martin, Baptiste Hoenen, Thomas Canard, Bruno Decroly, Etienne Antiviral Res Article This review focuses on the recent progress in our understanding of filovirus protein structure/function and its impact on antiviral research. Here we focus on the surface glycoprotein GP(1,2) and its different roles in filovirus entry. We first describe the latest advances on the characterization of GP gene-overlapping proteins sGP, ssGP and Δ-peptide. Then, we compare filovirus surface GP(1,2) proteins in terms of structure, synthesis and function. As they bear potential in drug-design, the discovery of small organic compounds inhibiting filovirus entry is a currently very active field. Although it is at an early stage, the development of antiviral drugs against Ebola and Marburg virus entry might prove essential to reduce outbreak-associated fatality rates through post-exposure treatment of both suspected and confirmed cases. Elsevier B.V. 2016-11 2016-09-14 /pmc/articles/PMC7113884/ /pubmed/27640102 http://dx.doi.org/10.1016/j.antiviral.2016.09.001 Text en © 2016 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Martin, Baptiste
Hoenen, Thomas
Canard, Bruno
Decroly, Etienne
Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
title Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
title_full Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
title_fullStr Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
title_full_unstemmed Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
title_short Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
title_sort filovirus proteins for antiviral drug discovery: a structure/function analysis of surface glycoproteins and virus entry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113884/
https://www.ncbi.nlm.nih.gov/pubmed/27640102
http://dx.doi.org/10.1016/j.antiviral.2016.09.001
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