Evaluation and comparison of the effect of honey, milk and combination of honey–milk on experimental induced second-degree burns of Rabit

INTRODUCTION: Burn can happen in any area and causes dominant changes in the quality of normal tissues. The aim of present article is evaluation and comparison the effect of milk, natural honey, and combination of honey–milk on healing of burnt wound. METHOD AND MATERIAL: A 4-week trial study was carried out on 10 Albino New Zealand rabbits. All dry burned wound was created on the back of the scapula by a 1 * 1 cm metal block. First group received honey dressing, second group milk dressing, third group honey–milk dressing, and the fourth group 5% sulfadiazine dressing. Sampling was performed at days 1, 10, and 20. Measurement of wound size was done in days 1, 7, 14, 21, 28. The obtained data and information were analyzed by two-way ANOVA and Duncan tests using SPSS. RESULTS: Result show that combination of milk-honey dressing had most significant effect on the improvement of wound healing in the recipient rabbits after a 4-week study. The size of burn wound in four different group was: Honey milk combination 0.428 cm(2), honey 0.547 cm(2), milk 0.579 cm(2) and sulfadiazine 0.873 cm(2). CONCLUSION: All dressing can accelerate wound healing and have promotive effect on wound healing but the combination of honey–milk had the greatest effect. Honey, milk, and sulfadiazine had next grade of effectiveness.