Cargando…
Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study
AIM: The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts. MATERIALS AND METHODS: It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous cysts (DC), 8 cases of radicular cysts (RC) and...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114001/ https://www.ncbi.nlm.nih.gov/pubmed/32318424 http://dx.doi.org/10.4103/jfmpc.jfmpc_1092_19 |
_version_ | 1783513790387585024 |
---|---|
author | Singh, Rohit Sisodia, Malwika Sengupta, Ranjan Bhindwar, Annu Prakash Bharti, Karuna Nafe, Md Abu |
author_facet | Singh, Rohit Sisodia, Malwika Sengupta, Ranjan Bhindwar, Annu Prakash Bharti, Karuna Nafe, Md Abu |
author_sort | Singh, Rohit |
collection | PubMed |
description | AIM: The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts. MATERIALS AND METHODS: It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous cysts (DC), 8 cases of radicular cysts (RC) and 8 dental follicles (DF) as controls which were immunohistochemically evaluated using an antibody against podoplanin. RESULTS: Immunostaining intensity, % of PPC and total score of ameloblastoma was higher than DC and DF but less than KCOT (t- 1.48). When DC was compared with KCOT and RC, the podoplanin expression was significantly higher with DC (P < 0.05). The podoplanin expression was comparatively higher with KCOT as compared to RC and DC. OT (t-4.40) revealed higher podoplanin expression as compared to OC and DF (t-5.54). CONCLUSION: There was significantly higher expression of podoplanin in cases of ameloblastoma and KCOT as compared to the RC, DC and DF. Podoplanin may be considered as a useful marker to delineate the aggressiveness of ameloblastoma and KCOT. |
format | Online Article Text |
id | pubmed-7114001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-71140012020-04-21 Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study Singh, Rohit Sisodia, Malwika Sengupta, Ranjan Bhindwar, Annu Prakash Bharti, Karuna Nafe, Md Abu J Family Med Prim Care Original Article AIM: The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts. MATERIALS AND METHODS: It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous cysts (DC), 8 cases of radicular cysts (RC) and 8 dental follicles (DF) as controls which were immunohistochemically evaluated using an antibody against podoplanin. RESULTS: Immunostaining intensity, % of PPC and total score of ameloblastoma was higher than DC and DF but less than KCOT (t- 1.48). When DC was compared with KCOT and RC, the podoplanin expression was significantly higher with DC (P < 0.05). The podoplanin expression was comparatively higher with KCOT as compared to RC and DC. OT (t-4.40) revealed higher podoplanin expression as compared to OC and DF (t-5.54). CONCLUSION: There was significantly higher expression of podoplanin in cases of ameloblastoma and KCOT as compared to the RC, DC and DF. Podoplanin may be considered as a useful marker to delineate the aggressiveness of ameloblastoma and KCOT. Wolters Kluwer - Medknow 2020-02-28 /pmc/articles/PMC7114001/ /pubmed/32318424 http://dx.doi.org/10.4103/jfmpc.jfmpc_1092_19 Text en Copyright: © Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Singh, Rohit Sisodia, Malwika Sengupta, Ranjan Bhindwar, Annu Prakash Bharti, Karuna Nafe, Md Abu Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study |
title | Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study |
title_full | Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study |
title_fullStr | Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study |
title_full_unstemmed | Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study |
title_short | Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study |
title_sort | assessment of expression of podoplanin in odontogenic tumors and cysts—an immunohistochemical study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114001/ https://www.ncbi.nlm.nih.gov/pubmed/32318424 http://dx.doi.org/10.4103/jfmpc.jfmpc_1092_19 |
work_keys_str_mv | AT singhrohit assessmentofexpressionofpodoplanininodontogenictumorsandcystsanimmunohistochemicalstudy AT sisodiamalwika assessmentofexpressionofpodoplanininodontogenictumorsandcystsanimmunohistochemicalstudy AT senguptaranjan assessmentofexpressionofpodoplanininodontogenictumorsandcystsanimmunohistochemicalstudy AT bhindwarannuprakash assessmentofexpressionofpodoplanininodontogenictumorsandcystsanimmunohistochemicalstudy AT bhartikaruna assessmentofexpressionofpodoplanininodontogenictumorsandcystsanimmunohistochemicalstudy AT nafemdabu assessmentofexpressionofpodoplanininodontogenictumorsandcystsanimmunohistochemicalstudy |