Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV

Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory sy...

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Detalles Bibliográficos
Autores principales: Brierley, Ian, Dos Ramos, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114087/
https://www.ncbi.nlm.nih.gov/pubmed/16310880
http://dx.doi.org/10.1016/j.virusres.2005.10.008
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author Brierley, Ian
Dos Ramos, Francisco J.
author_facet Brierley, Ian
Dos Ramos, Francisco J.
author_sort Brierley, Ian
collection PubMed
description Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS–CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.
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spelling pubmed-71140872020-04-02 Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV Brierley, Ian Dos Ramos, Francisco J. Virus Res Article Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS–CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed. Elsevier B.V. 2006-07 2005-11-28 /pmc/articles/PMC7114087/ /pubmed/16310880 http://dx.doi.org/10.1016/j.virusres.2005.10.008 Text en Copyright © 2005 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Brierley, Ian
Dos Ramos, Francisco J.
Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
title Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
title_full Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
title_fullStr Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
title_full_unstemmed Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
title_short Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
title_sort programmed ribosomal frameshifting in hiv-1 and the sars–cov
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114087/
https://www.ncbi.nlm.nih.gov/pubmed/16310880
http://dx.doi.org/10.1016/j.virusres.2005.10.008
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