A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of...

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Detalles Bibliográficos
Autores principales: Byrne, Hannah, Conroy, Paul J., Whisstock, James C., O’Kennedy, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114091/
https://www.ncbi.nlm.nih.gov/pubmed/24094861
http://dx.doi.org/10.1016/j.tibtech.2013.08.007
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author Byrne, Hannah
Conroy, Paul J.
Whisstock, James C.
O’Kennedy, Richard J.
author_facet Byrne, Hannah
Conroy, Paul J.
Whisstock, James C.
O’Kennedy, Richard J.
author_sort Byrne, Hannah
collection PubMed
description Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands. The next generation of bsAbs is developing due to significant improvements in recombinant antibody technologies. This review focuses on recent advances with a particular focus on improvements in format and design that are contributing to the resurgence of bsAbs, and in particular, on innovative structures applicable to next generation point-of-care (POC) devices with applicability to low resource environments.
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spelling pubmed-71140912020-04-02 A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications Byrne, Hannah Conroy, Paul J. Whisstock, James C. O’Kennedy, Richard J. Trends Biotechnol Review Artificial manipulation of antibody genes has facilitated the production of several unique recombinant antibody formats, which have highly important therapeutic and biotechnological applications. Although bispecific antibodies (bsAbs) are not new, they are coming to the forefront as our knowledge of the potential efficacy of antibody-based therapeutics expands. The next generation of bsAbs is developing due to significant improvements in recombinant antibody technologies. This review focuses on recent advances with a particular focus on improvements in format and design that are contributing to the resurgence of bsAbs, and in particular, on innovative structures applicable to next generation point-of-care (POC) devices with applicability to low resource environments. Elsevier Ltd. 2013-11 2013-10-02 /pmc/articles/PMC7114091/ /pubmed/24094861 http://dx.doi.org/10.1016/j.tibtech.2013.08.007 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Byrne, Hannah
Conroy, Paul J.
Whisstock, James C.
O’Kennedy, Richard J.
A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
title A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
title_full A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
title_fullStr A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
title_full_unstemmed A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
title_short A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
title_sort tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114091/
https://www.ncbi.nlm.nih.gov/pubmed/24094861
http://dx.doi.org/10.1016/j.tibtech.2013.08.007
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