A potential role for integrins in host cell entry by SARS-CoV-2

• Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surfac...

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Detalles Bibliográficos
Autores principales: Sigrist, Christian JA, Bridge, Alan, Le Mercier, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114098/
https://www.ncbi.nlm.nih.gov/pubmed/32130973
http://dx.doi.org/10.1016/j.antiviral.2020.104759
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author Sigrist, Christian JA
Bridge, Alan
Le Mercier, Philippe
author_facet Sigrist, Christian JA
Bridge, Alan
Le Mercier, Philippe
author_sort Sigrist, Christian JA
collection PubMed
description • Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.
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spelling pubmed-71140982020-04-02 A potential role for integrins in host cell entry by SARS-CoV-2 Sigrist, Christian JA Bridge, Alan Le Mercier, Philippe Antiviral Res Article • Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally. The Authors. Published by Elsevier B.V. 2020-05 2020-03-01 /pmc/articles/PMC7114098/ /pubmed/32130973 http://dx.doi.org/10.1016/j.antiviral.2020.104759 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sigrist, Christian JA
Bridge, Alan
Le Mercier, Philippe
A potential role for integrins in host cell entry by SARS-CoV-2
title A potential role for integrins in host cell entry by SARS-CoV-2
title_full A potential role for integrins in host cell entry by SARS-CoV-2
title_fullStr A potential role for integrins in host cell entry by SARS-CoV-2
title_full_unstemmed A potential role for integrins in host cell entry by SARS-CoV-2
title_short A potential role for integrins in host cell entry by SARS-CoV-2
title_sort potential role for integrins in host cell entry by sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114098/
https://www.ncbi.nlm.nih.gov/pubmed/32130973
http://dx.doi.org/10.1016/j.antiviral.2020.104759
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