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Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems

To date there is no effective treatment for bovine cryptosporidiosis. This study describes the use of halofuginone lactate in preventing cryptosporidiosis in naturally infected neonatal calves on a dairy farm with a high prevalence of infection. The animals were kept in two different calf rearing sy...

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Autores principales: De Waele, V., Speybroeck, N., Berkvens, D., Mulcahy, G., Murphy, T.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114106/
https://www.ncbi.nlm.nih.gov/pubmed/20692058
http://dx.doi.org/10.1016/j.prevetmed.2010.06.017
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author De Waele, V.
Speybroeck, N.
Berkvens, D.
Mulcahy, G.
Murphy, T.M.
author_facet De Waele, V.
Speybroeck, N.
Berkvens, D.
Mulcahy, G.
Murphy, T.M.
author_sort De Waele, V.
collection PubMed
description To date there is no effective treatment for bovine cryptosporidiosis. This study describes the use of halofuginone lactate in preventing cryptosporidiosis in naturally infected neonatal calves on a dairy farm with a high prevalence of infection. The animals were kept in two different calf rearing systems. A randomized double-blind trial was carried out with 32 naturally infected calves, divided into four groups. The two prophylactic halofuginone lactate treated groups were kept in either individual or group pens. Similarly, the animals receiving the placebo were housed in either individual pens or together in a large pen. A total of ten faecal samples were collected periodically during the 28 days study from each calf and tested for the presence of Cryptosporidium spp. using microscopic and molecular methods. Generalized estimating equations models were used to determine if the effects of the various treatments and/or rearing systems on the presence of diarrhoea and infection were statistically significant. Further analysis (classification trees models) was carried out to explore possible risk factors for cryptosporidiosis and interactions between treatments and rearing systems. Halofuginone lactate was shown to be effective in reducing clinical signs of cryptosporidiosis and environmental contamination. However, the treatment did not delay the onset of diarrhoea and did not reduce the risk of infection amongst calves reared together in a highly contaminated environment. The use of halofuginone lactate in combination with good hygienic measures, such as rearing animals in clean individual pens, was the most effective method to reduce the risk of cryptosporidiosis amongst 7–13 days old calves. It was concluded that the control of the parasite could be achieved by the combination of using effective preventive drugs, such as halofuginone lactate and good animal husbandry procedures.
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spelling pubmed-71141062020-04-02 Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems De Waele, V. Speybroeck, N. Berkvens, D. Mulcahy, G. Murphy, T.M. Prev Vet Med Article To date there is no effective treatment for bovine cryptosporidiosis. This study describes the use of halofuginone lactate in preventing cryptosporidiosis in naturally infected neonatal calves on a dairy farm with a high prevalence of infection. The animals were kept in two different calf rearing systems. A randomized double-blind trial was carried out with 32 naturally infected calves, divided into four groups. The two prophylactic halofuginone lactate treated groups were kept in either individual or group pens. Similarly, the animals receiving the placebo were housed in either individual pens or together in a large pen. A total of ten faecal samples were collected periodically during the 28 days study from each calf and tested for the presence of Cryptosporidium spp. using microscopic and molecular methods. Generalized estimating equations models were used to determine if the effects of the various treatments and/or rearing systems on the presence of diarrhoea and infection were statistically significant. Further analysis (classification trees models) was carried out to explore possible risk factors for cryptosporidiosis and interactions between treatments and rearing systems. Halofuginone lactate was shown to be effective in reducing clinical signs of cryptosporidiosis and environmental contamination. However, the treatment did not delay the onset of diarrhoea and did not reduce the risk of infection amongst calves reared together in a highly contaminated environment. The use of halofuginone lactate in combination with good hygienic measures, such as rearing animals in clean individual pens, was the most effective method to reduce the risk of cryptosporidiosis amongst 7–13 days old calves. It was concluded that the control of the parasite could be achieved by the combination of using effective preventive drugs, such as halofuginone lactate and good animal husbandry procedures. Elsevier B.V. 2010-09-01 2010-08-09 /pmc/articles/PMC7114106/ /pubmed/20692058 http://dx.doi.org/10.1016/j.prevetmed.2010.06.017 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
De Waele, V.
Speybroeck, N.
Berkvens, D.
Mulcahy, G.
Murphy, T.M.
Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems
title Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems
title_full Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems
title_fullStr Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems
title_full_unstemmed Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems
title_short Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems
title_sort control of cryptosporidiosis in neonatal calves: use of halofuginone lactate in two different calf rearing systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114106/
https://www.ncbi.nlm.nih.gov/pubmed/20692058
http://dx.doi.org/10.1016/j.prevetmed.2010.06.017
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