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Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication

Understanding the fundamental steps of virus life cycles including virus–host interactions is essential for the design of effective antiviral strategies. Such understanding has been deferred by the complexity of higher eukaryotic host organisms. To circumvent experimental difficulties associated wit...

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Detalles Bibliográficos
Autores principales: Alves-Rodrigues, Isabel, Galão, Rui Pedro, Meyerhans, Andreas, Díez, Juana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114155/
https://www.ncbi.nlm.nih.gov/pubmed/16698107
http://dx.doi.org/10.1016/j.virusres.2005.11.018
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author Alves-Rodrigues, Isabel
Galão, Rui Pedro
Meyerhans, Andreas
Díez, Juana
author_facet Alves-Rodrigues, Isabel
Galão, Rui Pedro
Meyerhans, Andreas
Díez, Juana
author_sort Alves-Rodrigues, Isabel
collection PubMed
description Understanding the fundamental steps of virus life cycles including virus–host interactions is essential for the design of effective antiviral strategies. Such understanding has been deferred by the complexity of higher eukaryotic host organisms. To circumvent experimental difficulties associated with this, systems were developed to replicate viruses in the yeast Saccharomyces cerevisiae. The systems include viruses with RNA and DNA genomes that infect plants, animals and humans. By using the powerful methodologies available for yeast genetic analysis, fundamental processes occurring during virus replication have been brought to light. Here, we review the different viruses able to direct replication and gene expression in yeast and discuss their main contributions in the understanding of virus biology.
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spelling pubmed-71141552020-04-02 Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication Alves-Rodrigues, Isabel Galão, Rui Pedro Meyerhans, Andreas Díez, Juana Virus Res Article Understanding the fundamental steps of virus life cycles including virus–host interactions is essential for the design of effective antiviral strategies. Such understanding has been deferred by the complexity of higher eukaryotic host organisms. To circumvent experimental difficulties associated with this, systems were developed to replicate viruses in the yeast Saccharomyces cerevisiae. The systems include viruses with RNA and DNA genomes that infect plants, animals and humans. By using the powerful methodologies available for yeast genetic analysis, fundamental processes occurring during virus replication have been brought to light. Here, we review the different viruses able to direct replication and gene expression in yeast and discuss their main contributions in the understanding of virus biology. Elsevier B.V. 2006-09 2006-05-15 /pmc/articles/PMC7114155/ /pubmed/16698107 http://dx.doi.org/10.1016/j.virusres.2005.11.018 Text en Copyright © 2005 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Alves-Rodrigues, Isabel
Galão, Rui Pedro
Meyerhans, Andreas
Díez, Juana
Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication
title Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication
title_full Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication
title_fullStr Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication
title_full_unstemmed Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication
title_short Saccharomyces cerevisiae: A useful model host to study fundamental biology of viral replication
title_sort saccharomyces cerevisiae: a useful model host to study fundamental biology of viral replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114155/
https://www.ncbi.nlm.nih.gov/pubmed/16698107
http://dx.doi.org/10.1016/j.virusres.2005.11.018
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