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A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

In vitro infection of Vero E6 cells by SARS coronavirus (SARS-CoV) is blocked by hexapeptide Tyr-Lys-Tyr-Arg-Tyr-Leu. The peptide also inhibits proliferation of coronavirus NL63. On human cells both viruses utilize angiotensin-converting enzyme 2 (ACE2) as entry receptor. Blocking the viral entry is...

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Detalles Bibliográficos
Autores principales:	Struck, Anna-Winona, Axmann, Marco, Pfefferle, Susanne, Drosten, Christian, Meyer, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114193/ https://www.ncbi.nlm.nih.gov/pubmed/22265858 http://dx.doi.org/10.1016/j.antiviral.2011.12.012

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