Cargando…
Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum
We have previously reported a new class of dendrimers with tryptophan (Trp) residues on the surface that show dual antiviral activities against HIV and enterovirus EV71. The prototype compound of this family is a derivative of pentaerythritol with 12 peripheral Trp groups and trivalent spacer arms....
Autores principales: | Martínez-Gualda, Belén, Sun, Liang, Martí-Marí, Olaia, Mirabelli, Carmen, Delang, Leen, Neyts, Johan, Schols, Dominique, Camarasa, María-José, San-Félix, Ana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114229/ https://www.ncbi.nlm.nih.gov/pubmed/31228490 http://dx.doi.org/10.1016/j.antiviral.2019.06.006 |
Ejemplares similares
-
Double Arylation
of the Indole Side Chain of Tri-
and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1
and EV-A71 Entry Inhibitors†
por: Martí-Marí, Olaia, et al.
Publicado: (2021) -
Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates
por: Martí-Marí, Olaia, et al.
Publicado: (2023) -
Multivalent Tryptophan‐ and Tyrosine‐Containing [60]Fullerene Hexa‐Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors
por: Ruiz‐Santaquiteria, Marta, et al.
Publicado: (2021) -
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid
por: Sun, Liang, et al.
Publicado: (2019) -
Towards antivirals against chikungunya virus
por: Abdelnabi, Rana, et al.
Publicado: (2015)