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Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

SARS coronavirus main protease (SARS-CoV M(pro)) is essential for the replication of the virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with a catalytic dyad (Cys-145/His-41) in the active site. Aldehyde inhibitors can bind reversibly to the active-site sulfh...

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Detalles Bibliográficos
Autores principales:	Zhu, Lili, George, Shyla, Schmidt, Marco F., Al-Gharabli, Samer I., Rademann, Jörg, Hilgenfeld, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114241/ https://www.ncbi.nlm.nih.gov/pubmed/21854807 http://dx.doi.org/10.1016/j.antiviral.2011.08.001

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