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Composition bias and genome polarity of RNA viruses

I have observed a relationship between GC content in coding sequences of RNA viruses and their genome polarity. Positive-stranded RNA viruses have significantly higher GC contents than negative-stranded RNA viruses. Coding sequences of all negative-stranded RNA viruses are biased toward high A in co...

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Autor principal: Auewarakul, Prasert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114242/
https://www.ncbi.nlm.nih.gov/pubmed/15826910
http://dx.doi.org/10.1016/j.virusres.2004.10.004
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author Auewarakul, Prasert
author_facet Auewarakul, Prasert
author_sort Auewarakul, Prasert
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description I have observed a relationship between GC content in coding sequences of RNA viruses and their genome polarity. Positive-stranded RNA viruses have significantly higher GC contents than negative-stranded RNA viruses. Coding sequences of all negative-stranded RNA viruses are biased toward high A in coding strands (high T in genomes), while two distinct patterns were observed among positive-stranded RNA genomes. This finding suggests that RNA viruses with different genome polarity are under different mutational pressure, which may be a consequence of the difference in the strategies of viral genome expression and replication. The GC content directly affects the viral codon adaptation index using highly expressed human genes as the reference set, which may theoretically predict the efficiency of viral gene expression in human cells.
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spelling pubmed-71142422020-04-02 Composition bias and genome polarity of RNA viruses Auewarakul, Prasert Virus Res Article I have observed a relationship between GC content in coding sequences of RNA viruses and their genome polarity. Positive-stranded RNA viruses have significantly higher GC contents than negative-stranded RNA viruses. Coding sequences of all negative-stranded RNA viruses are biased toward high A in coding strands (high T in genomes), while two distinct patterns were observed among positive-stranded RNA genomes. This finding suggests that RNA viruses with different genome polarity are under different mutational pressure, which may be a consequence of the difference in the strategies of viral genome expression and replication. The GC content directly affects the viral codon adaptation index using highly expressed human genes as the reference set, which may theoretically predict the efficiency of viral gene expression in human cells. Elsevier B.V. 2005-04 2004-11-18 /pmc/articles/PMC7114242/ /pubmed/15826910 http://dx.doi.org/10.1016/j.virusres.2004.10.004 Text en Copyright © 2004 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Auewarakul, Prasert
Composition bias and genome polarity of RNA viruses
title Composition bias and genome polarity of RNA viruses
title_full Composition bias and genome polarity of RNA viruses
title_fullStr Composition bias and genome polarity of RNA viruses
title_full_unstemmed Composition bias and genome polarity of RNA viruses
title_short Composition bias and genome polarity of RNA viruses
title_sort composition bias and genome polarity of rna viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114242/
https://www.ncbi.nlm.nih.gov/pubmed/15826910
http://dx.doi.org/10.1016/j.virusres.2004.10.004
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