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Viruses as vesicular carriers of the viral genome: A functional module perspective

Enveloped viruses and cellular transport vesicles share obvious morphological and functional properties. Both are composed of a closed membrane, which is lined with coat proteins and encases cargo. Transmembrane proteins inserted into the membrane define the target membrane area with which the vesic...

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Detalles Bibliográficos
Autores principales: Thaa, Bastian, Hofmann, Klaus Peter, Veit, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114299/
https://www.ncbi.nlm.nih.gov/pubmed/20100522
http://dx.doi.org/10.1016/j.bbamcr.2010.01.011
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author Thaa, Bastian
Hofmann, Klaus Peter
Veit, Michael
author_facet Thaa, Bastian
Hofmann, Klaus Peter
Veit, Michael
author_sort Thaa, Bastian
collection PubMed
description Enveloped viruses and cellular transport vesicles share obvious morphological and functional properties. Both are composed of a closed membrane, which is lined with coat proteins and encases cargo. Transmembrane proteins inserted into the membrane define the target membrane area with which the vesicle or virus is destined to fuse. Here we discuss recent insight into the functioning of enveloped viruses in the framework of the “functional module” concept. Vesicular transport is an exemplary case of a functional module, as defined as a part of the proteome that assembles to perform a specific autonomous function in a living cell. Cellular vesicles serve to transport cargo between membranous organelles inside the cell, while enveloped viruses can be seen as carriers of the viral genome delivering their cargo from an infected to an uninfected cell. The turnover of both vesicles and viruses involves an analogous series of submodular events. This comprises assembly of elements, budding from the donor compartment, uncoating and/or maturation, docking to and finally fusion with the target membrane to release the cargo. This modular perception enables us to define submodular building blocks so that mechanisms and elements can be directly compared. It will be analyzed where viruses have developed their own specific strategy, where they share functional schemes with vesicles, and also where they even have “hijacked” complete submodular schemes from the cell. Such a perspective may also include new and more specific approaches to pharmacological interference with virus function, which could avoid some of the most severe side effects.
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spelling pubmed-71142992020-04-02 Viruses as vesicular carriers of the viral genome: A functional module perspective Thaa, Bastian Hofmann, Klaus Peter Veit, Michael Biochim Biophys Acta Mol Cell Res Review Enveloped viruses and cellular transport vesicles share obvious morphological and functional properties. Both are composed of a closed membrane, which is lined with coat proteins and encases cargo. Transmembrane proteins inserted into the membrane define the target membrane area with which the vesicle or virus is destined to fuse. Here we discuss recent insight into the functioning of enveloped viruses in the framework of the “functional module” concept. Vesicular transport is an exemplary case of a functional module, as defined as a part of the proteome that assembles to perform a specific autonomous function in a living cell. Cellular vesicles serve to transport cargo between membranous organelles inside the cell, while enveloped viruses can be seen as carriers of the viral genome delivering their cargo from an infected to an uninfected cell. The turnover of both vesicles and viruses involves an analogous series of submodular events. This comprises assembly of elements, budding from the donor compartment, uncoating and/or maturation, docking to and finally fusion with the target membrane to release the cargo. This modular perception enables us to define submodular building blocks so that mechanisms and elements can be directly compared. It will be analyzed where viruses have developed their own specific strategy, where they share functional schemes with vesicles, and also where they even have “hijacked” complete submodular schemes from the cell. Such a perspective may also include new and more specific approaches to pharmacological interference with virus function, which could avoid some of the most severe side effects. Elsevier B.V. 2010-04 2010-01-25 /pmc/articles/PMC7114299/ /pubmed/20100522 http://dx.doi.org/10.1016/j.bbamcr.2010.01.011 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Thaa, Bastian
Hofmann, Klaus Peter
Veit, Michael
Viruses as vesicular carriers of the viral genome: A functional module perspective
title Viruses as vesicular carriers of the viral genome: A functional module perspective
title_full Viruses as vesicular carriers of the viral genome: A functional module perspective
title_fullStr Viruses as vesicular carriers of the viral genome: A functional module perspective
title_full_unstemmed Viruses as vesicular carriers of the viral genome: A functional module perspective
title_short Viruses as vesicular carriers of the viral genome: A functional module perspective
title_sort viruses as vesicular carriers of the viral genome: a functional module perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114299/
https://www.ncbi.nlm.nih.gov/pubmed/20100522
http://dx.doi.org/10.1016/j.bbamcr.2010.01.011
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