SP600125 inhibits Orthopoxviruses replication in a JNK1/2 -independent manner: Implication as a potential antipoxviral

The pharmacological inhibitor SP600125 [anthra(1,9-cd)pyrazol-6(2H)-one 1,9-pyrazoloanthrone] has been largely employed as a c-JUN N-terminal kinase (JNK1/2) inhibitor. In this study, we evaluated whether pretreatment with SP600125 was able to prevent Orthopoxviruses Vaccinia virus (VACV), Cowpox vi...

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Detalles Bibliográficos
Autores principales: Pereira, Anna C.T.C., Soares-Martins, Jamária A.P., Leite, Flávia G.G., Da Cruz, André F.P., Torres, Alice A., Souto-Padrón, Thais, Kroon, Erna G., Ferreira, Paulo C.P., Bonjardim, Cláudio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114308/
https://www.ncbi.nlm.nih.gov/pubmed/22068148
http://dx.doi.org/10.1016/j.antiviral.2011.10.020

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