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Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers()
Two-pore channels (TPCs) are Ca(2+)-permeable ion channels localised to the endo-lysosomal system where they regulate trafficking of various cargoes including viruses. As a result, TPCs are emerging as important drug targets. However, their pharmacology is ill-defined. There are no approved drugs to...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier B.V.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114365/ https://www.ncbi.nlm.nih.gov/pubmed/30408544 http://dx.doi.org/10.1016/j.bbamcr.2018.10.022 |