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Rhabdovirus accessory genes
The Rhabdoviridae is one of the most ecologically diverse families of RNA viruses with members infecting a wide range of organisms including placental mammals, marsupials, birds, reptiles, fish, insects and plants. The availability of complete nucleotide sequences for an increasing number of rhabdov...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier B.V.
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114375/ https://www.ncbi.nlm.nih.gov/pubmed/21933691 http://dx.doi.org/10.1016/j.virusres.2011.09.004 |
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author | Walker, Peter J. Dietzgen, Ralf G. Joubert, D. Albert Blasdell, Kim R. |
author_facet | Walker, Peter J. Dietzgen, Ralf G. Joubert, D. Albert Blasdell, Kim R. |
author_sort | Walker, Peter J. |
collection | PubMed |
description | The Rhabdoviridae is one of the most ecologically diverse families of RNA viruses with members infecting a wide range of organisms including placental mammals, marsupials, birds, reptiles, fish, insects and plants. The availability of complete nucleotide sequences for an increasing number of rhabdoviruses has revealed that their ecological diversity is reflected in the diversity and complexity of their genomes. The five canonical rhabdovirus structural protein genes (N, P, M, G and L) that are shared by all rhabdoviruses are overprinted, overlapped and interspersed with a multitude of novel and diverse accessory genes. Although not essential for replication in cell culture, several of these genes have been shown to have roles associated with pathogenesis and apoptosis in animals, and cell-to-cell movement in plants. Others appear to be secreted or have the characteristics of membrane-anchored glycoproteins or viroporins. However, most encode proteins of unknown function that are unrelated to any other known proteins. Understanding the roles of these accessory genes and the strategies by which rhabdoviruses use them to engage, divert and re-direct cellular processes will not only present opportunities to develop new anti-viral therapies but may also reveal aspects of cellar function that have broader significance in biology, agriculture and medicine. |
format | Online Article Text |
id | pubmed-7114375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71143752020-04-02 Rhabdovirus accessory genes Walker, Peter J. Dietzgen, Ralf G. Joubert, D. Albert Blasdell, Kim R. Virus Res Article The Rhabdoviridae is one of the most ecologically diverse families of RNA viruses with members infecting a wide range of organisms including placental mammals, marsupials, birds, reptiles, fish, insects and plants. The availability of complete nucleotide sequences for an increasing number of rhabdoviruses has revealed that their ecological diversity is reflected in the diversity and complexity of their genomes. The five canonical rhabdovirus structural protein genes (N, P, M, G and L) that are shared by all rhabdoviruses are overprinted, overlapped and interspersed with a multitude of novel and diverse accessory genes. Although not essential for replication in cell culture, several of these genes have been shown to have roles associated with pathogenesis and apoptosis in animals, and cell-to-cell movement in plants. Others appear to be secreted or have the characteristics of membrane-anchored glycoproteins or viroporins. However, most encode proteins of unknown function that are unrelated to any other known proteins. Understanding the roles of these accessory genes and the strategies by which rhabdoviruses use them to engage, divert and re-direct cellular processes will not only present opportunities to develop new anti-viral therapies but may also reveal aspects of cellar function that have broader significance in biology, agriculture and medicine. Published by Elsevier B.V. 2011-12 2011-09-14 /pmc/articles/PMC7114375/ /pubmed/21933691 http://dx.doi.org/10.1016/j.virusres.2011.09.004 Text en Crown copyright © 2011 Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Walker, Peter J. Dietzgen, Ralf G. Joubert, D. Albert Blasdell, Kim R. Rhabdovirus accessory genes |
title | Rhabdovirus accessory genes |
title_full | Rhabdovirus accessory genes |
title_fullStr | Rhabdovirus accessory genes |
title_full_unstemmed | Rhabdovirus accessory genes |
title_short | Rhabdovirus accessory genes |
title_sort | rhabdovirus accessory genes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114375/ https://www.ncbi.nlm.nih.gov/pubmed/21933691 http://dx.doi.org/10.1016/j.virusres.2011.09.004 |
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