Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus

Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung inju...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Yang, Ning, Tang, Jun, Liu, Song, Luo, Deyan, Duan, Qing, Wang, Xiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. Published by Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114376/
https://www.ncbi.nlm.nih.gov/pubmed/24662240
http://dx.doi.org/10.1016/j.virusres.2014.03.010
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author Liu, Xin
Yang, Ning
Tang, Jun
Liu, Song
Luo, Deyan
Duan, Qing
Wang, Xiliang
author_facet Liu, Xin
Yang, Ning
Tang, Jun
Liu, Song
Luo, Deyan
Duan, Qing
Wang, Xiliang
author_sort Liu, Xin
collection PubMed
description Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed that ACE2 protein levels were significantly downregulated after infection with H1N1 viruses but was dispensable for viral replication. ACE2 protein downregulation was most likely related to ACE2 protein degradation by proteasome pathway rather than ACE2 shedding. Finally, we found that ACE2 cleavage could be regulated by influenza neuraminidase (NA), which was fundamentally different from the classically sheddase-induced proteolytic cleavage of ACE2.
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spelling pubmed-71143762020-04-02 Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus Liu, Xin Yang, Ning Tang, Jun Liu, Song Luo, Deyan Duan, Qing Wang, Xiliang Virus Res Article Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed that ACE2 protein levels were significantly downregulated after infection with H1N1 viruses but was dispensable for viral replication. ACE2 protein downregulation was most likely related to ACE2 protein degradation by proteasome pathway rather than ACE2 shedding. Finally, we found that ACE2 cleavage could be regulated by influenza neuraminidase (NA), which was fundamentally different from the classically sheddase-induced proteolytic cleavage of ACE2. Elsevier B.V. Published by Elsevier B.V. 2014-06-24 2014-03-21 /pmc/articles/PMC7114376/ /pubmed/24662240 http://dx.doi.org/10.1016/j.virusres.2014.03.010 Text en Copyright © 2014 Elsevier B.V. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Liu, Xin
Yang, Ning
Tang, Jun
Liu, Song
Luo, Deyan
Duan, Qing
Wang, Xiliang
Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus
title Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus
title_full Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus
title_fullStr Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus
title_full_unstemmed Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus
title_short Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus
title_sort downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza a (h1n1) virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114376/
https://www.ncbi.nlm.nih.gov/pubmed/24662240
http://dx.doi.org/10.1016/j.virusres.2014.03.010
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