Intracerebral delivery of small interfering RNAs (siRNAs) using adenoviral vector protects mice against lethal peripheral rabies challenge

To investigate the potential of RNA interference (RNAi) as antiviral agent against rabies, two small interfering RNAs (siRNAs) targeting rabies virus (RABV) nucleoprotein (N) and polymerase (L) genes were designed and evaluated. Both siRNAs knockdown or silenced the target RABV genes as evaluated in...

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Detalles Bibliográficos
Autores principales: Gupta, Praveen K., Sonwane, Arvind A., Singh, Niraj K., Meshram, Chetan D., Dahiya, Shyam S., Pawar, Sachin S., Gupta, Swatantra P., Chaturvedi, V.K., Saini, Mohini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114402/
https://www.ncbi.nlm.nih.gov/pubmed/21864591
http://dx.doi.org/10.1016/j.virusres.2011.08.004

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