A study of the virulence in mice of high copying fidelity variants of human enterovirus 71

Polioviruses with a G64S mutation in the 3D polymerase have enhanced replication fidelity and are attenuated in animal models. Here we describe the mouse virulence properties of high replication fidelity 3D polymerase variants of human enterovirus 71 (HEV71), with mutations at positions 3D-S264L, 3D...

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Detalles Bibliográficos
Autores principales: Sadeghipour, Sara, McMinn, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114468/
https://www.ncbi.nlm.nih.gov/pubmed/23856384
http://dx.doi.org/10.1016/j.virusres.2013.06.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114468/
https://www.ncbi.nlm.nih.gov/pubmed/23856384
http://dx.doi.org/10.1016/j.virusres.2013.06.019

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