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Atlas of coronavirus replicase structure

The international response to SARS-CoV has produced an outstanding number of protein structures in a very short time. This review summarizes the findings of functional and structural studies including those derived from cryoelectron microscopy, small angle X-ray scattering, NMR spectroscopy, and X-r...

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Detalles Bibliográficos
Autores principales: Neuman, Benjamin W., Chamberlain, Peter, Bowden, Fern, Joseph, Jeremiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114488/
https://www.ncbi.nlm.nih.gov/pubmed/24355834
http://dx.doi.org/10.1016/j.virusres.2013.12.004
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author Neuman, Benjamin W.
Chamberlain, Peter
Bowden, Fern
Joseph, Jeremiah
author_facet Neuman, Benjamin W.
Chamberlain, Peter
Bowden, Fern
Joseph, Jeremiah
author_sort Neuman, Benjamin W.
collection PubMed
description The international response to SARS-CoV has produced an outstanding number of protein structures in a very short time. This review summarizes the findings of functional and structural studies including those derived from cryoelectron microscopy, small angle X-ray scattering, NMR spectroscopy, and X-ray crystallography, and incorporates bioinformatics predictions where no structural data is available. Structures that shed light on the function and biological roles of the proteins in viral replication and pathogenesis are highlighted. The high percentage of novel protein folds identified among SARS-CoV proteins is discussed.
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spelling pubmed-71144882020-04-02 Atlas of coronavirus replicase structure Neuman, Benjamin W. Chamberlain, Peter Bowden, Fern Joseph, Jeremiah Virus Res Article The international response to SARS-CoV has produced an outstanding number of protein structures in a very short time. This review summarizes the findings of functional and structural studies including those derived from cryoelectron microscopy, small angle X-ray scattering, NMR spectroscopy, and X-ray crystallography, and incorporates bioinformatics predictions where no structural data is available. Structures that shed light on the function and biological roles of the proteins in viral replication and pathogenesis are highlighted. The high percentage of novel protein folds identified among SARS-CoV proteins is discussed. Elsevier B.V. 2014-12-19 2013-12-16 /pmc/articles/PMC7114488/ /pubmed/24355834 http://dx.doi.org/10.1016/j.virusres.2013.12.004 Text en Copyright © 2013 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Neuman, Benjamin W.
Chamberlain, Peter
Bowden, Fern
Joseph, Jeremiah
Atlas of coronavirus replicase structure
title Atlas of coronavirus replicase structure
title_full Atlas of coronavirus replicase structure
title_fullStr Atlas of coronavirus replicase structure
title_full_unstemmed Atlas of coronavirus replicase structure
title_short Atlas of coronavirus replicase structure
title_sort atlas of coronavirus replicase structure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114488/
https://www.ncbi.nlm.nih.gov/pubmed/24355834
http://dx.doi.org/10.1016/j.virusres.2013.12.004
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