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Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506

Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As s...

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Detalles Bibliográficos
Autores principales:	Carbajo-Lozoya, Javier, Müller, Marcel A., Kallies, Stephan, Thiel, Volker, Drosten, Christian, von Brunn, Albrecht
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114512/ https://www.ncbi.nlm.nih.gov/pubmed/22349148 http://dx.doi.org/10.1016/j.virusres.2012.02.002

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