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Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus
To study the roles of hypervariable regions (HVRs) in receptor-binding subunit S1 of the spike protein, we manipulated the genome of the IBV Beaudette strain using a reverse genetics system to construct seven recombinant strains by separately or simultaneously replacing the three HVRs of the Beaudet...
Autores principales: | Shan, Dan, Fang, Shouguo, Han, Zongxi, Ai, Hui, Zhao, Wenjun, Chen, Yuqiu, Jiang, Lei, Liu, Shengwang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114591/ https://www.ncbi.nlm.nih.gov/pubmed/29684409 http://dx.doi.org/10.1016/j.virusres.2018.04.013 |
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