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Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity

We previously developed integrase-defective lentiviral vectors (IDLVs) as an antigen delivery system for inducing strong and prolonged immunity in animal models. Here, we examined the association between persistence of antigen expression and durability of immune response. Following a single intramus...

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Detalles Bibliográficos
Autores principales: Lin, Yi-Yu, Belle, Ian, Blasi, Maria, Huang, Min-Nung, Buckley, Anne F., Rountree, Wes, Klotman, Mary E., Cara, Andrea, Negri, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114633/
https://www.ncbi.nlm.nih.gov/pubmed/32258216
http://dx.doi.org/10.1016/j.omtm.2020.03.008

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