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A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection

One of the most important anthropic missions is preventing the global spread of infectious diseases. Vaccination is the only available preventive treatment for infectious diseases, but the availability of vaccines in developing countries is not adequate. We report a simple, easy-to-use, noninvasive...

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Autores principales: Ishii, Yumiko, Nakae, Tomoko, Sakamoto, Fumiko, Matsuo, Kazuhiko, Matsuo, Keisuke, Quan, Ying-Shu, Kamiyama, Fumio, Fujita, Takuya, Yamamoto, Akira, Nakagawa, Shinsaku, Okada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114651/
https://www.ncbi.nlm.nih.gov/pubmed/18700159
http://dx.doi.org/10.1016/j.jconrel.2008.07.025
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author Ishii, Yumiko
Nakae, Tomoko
Sakamoto, Fumiko
Matsuo, Kazuhiko
Matsuo, Keisuke
Quan, Ying-Shu
Kamiyama, Fumio
Fujita, Takuya
Yamamoto, Akira
Nakagawa, Shinsaku
Okada, Naoki
author_facet Ishii, Yumiko
Nakae, Tomoko
Sakamoto, Fumiko
Matsuo, Kazuhiko
Matsuo, Keisuke
Quan, Ying-Shu
Kamiyama, Fumio
Fujita, Takuya
Yamamoto, Akira
Nakagawa, Shinsaku
Okada, Naoki
author_sort Ishii, Yumiko
collection PubMed
description One of the most important anthropic missions is preventing the global spread of infectious diseases. Vaccination is the only available preventive treatment for infectious diseases, but the availability of vaccines in developing countries is not adequate. We report a simple, easy-to-use, noninvasive hydrogel patch transcutaneous vaccination system. Antigen (Ag)-specific IgG production was induced by applying an Ag-immersed patch to non-pretreated mouse auricle or hairless rat back skin. Immunofluorescence histochemical analysis revealed that Langerhans cells resident in the epidermal layer captured the antigenic proteins delivered by the hydrogel patch, which promoted the penetration of antigenic proteins through the stratum corneum, and that Ag-capturing Langerhans cells migrated into draining lymph nodes. Humoral immunity elicited by our transcutaneous vaccination system demonstrated neutralizing activity in both adenoviral infection and passive-challenge tetanus toxin experiments. The use of this hydrogel patch transcutaneous vaccination system will facilitate the global distribution of effective and convenient vaccines.
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spelling pubmed-71146512020-04-02 A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection Ishii, Yumiko Nakae, Tomoko Sakamoto, Fumiko Matsuo, Kazuhiko Matsuo, Keisuke Quan, Ying-Shu Kamiyama, Fumio Fujita, Takuya Yamamoto, Akira Nakagawa, Shinsaku Okada, Naoki J Control Release Article One of the most important anthropic missions is preventing the global spread of infectious diseases. Vaccination is the only available preventive treatment for infectious diseases, but the availability of vaccines in developing countries is not adequate. We report a simple, easy-to-use, noninvasive hydrogel patch transcutaneous vaccination system. Antigen (Ag)-specific IgG production was induced by applying an Ag-immersed patch to non-pretreated mouse auricle or hairless rat back skin. Immunofluorescence histochemical analysis revealed that Langerhans cells resident in the epidermal layer captured the antigenic proteins delivered by the hydrogel patch, which promoted the penetration of antigenic proteins through the stratum corneum, and that Ag-capturing Langerhans cells migrated into draining lymph nodes. Humoral immunity elicited by our transcutaneous vaccination system demonstrated neutralizing activity in both adenoviral infection and passive-challenge tetanus toxin experiments. The use of this hydrogel patch transcutaneous vaccination system will facilitate the global distribution of effective and convenient vaccines. Elsevier B.V. 2008-10-21 2008-07-23 /pmc/articles/PMC7114651/ /pubmed/18700159 http://dx.doi.org/10.1016/j.jconrel.2008.07.025 Text en Copyright © 2008 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ishii, Yumiko
Nakae, Tomoko
Sakamoto, Fumiko
Matsuo, Kazuhiko
Matsuo, Keisuke
Quan, Ying-Shu
Kamiyama, Fumio
Fujita, Takuya
Yamamoto, Akira
Nakagawa, Shinsaku
Okada, Naoki
A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
title A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
title_full A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
title_fullStr A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
title_full_unstemmed A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
title_short A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
title_sort transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114651/
https://www.ncbi.nlm.nih.gov/pubmed/18700159
http://dx.doi.org/10.1016/j.jconrel.2008.07.025
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