Cargando…

Glycosylation Heterogeneity of Hyperglycosylated Recombinant Human Interferon-β (rhIFN-β)

[Image: see text] We previously developed a biobetter version of rhIFN-β (R27T) that possesses an additional glycosylation site compared with rhIFN-β 1a. Herein, we characterized N-glycosylation heterogeneity of R27T, which includes both N-glycan site occupancy heterogeneity (macro-heterogeneity) an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Kyoung, Moon, Dae Bong, Kim, Na Young, Shin, Young Kee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114697/ https://www.ncbi.nlm.nih.gov/pubmed/32258897 http://dx.doi.org/10.1021/acsomega.9b04385

Ejemplares similares

Overexpression of the recombinant human interferon-beta (rhIFN-β) gene in tobacco chloroplasts
por: Feizi, Asghar, et al.
Publicado: (2021)

Stability and Activity of the Hyperglycosylated Human Interferon-β R27T Variant
por: Song, Kyoung, et al.
Publicado: (2020)

Enhanced delivery efficiency and sustained release of biopharmaceuticals by complexation-based gel encapsulated coated microneedles: rhIFNα-1b example
por: Zhou, Zequan, et al.
Publicado: (2021)

Differences in the production of hyperglycosylated IFN alpha in CHO and HEK 293 cells
por: Gugliotta, Agustina, et al.
Publicado: (2013)

Transient hyperglycosylation of rhodopsin with galactose
por: Smith, Sylvia B., et al.
Publicado: (1991)

Overexpression of Recombinant Human Beta Interferon (rhINF-β) in Periplasmic Space of Escherichia coli
por: Morowvat, Mohammad Hossein, et al.
Publicado: (2014)

Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist()
por: Killip, M.J., et al.
Publicado: (2011)

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization
por: Thornlow, Dana N., et al.
Publicado: (2021)

Semiprocessive Hyperglycosylation of Adhesin by Bacterial Protein N-Glycosyltransferases
por: Yakovlieva, Liubov, et al.
Publicado: (2021)

Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal Irradiation
por: Hamade, Diala F., et al.
Publicado: (2023)

Biotransformation of Ginsenoside Rf to Rh(1) by Recombinant β-Glucosidase
por: Ruan, Chang-Chun, et al.
Publicado: (2009)

Insights into the hyperglycosylation of human chorionic gonadotropin revealed by glycomics analysis
por: Ibeto, Linda, et al.
Publicado: (2020)

The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β
por: Balkhi, Sayed Sharif, et al.
Publicado: (2019)

The Differential Antiviral Activities of Chicken Interferon α (ChIFN-α) and ChIFN-β are Related to Distinct Interferon-Stimulated Gene Expression
por: Qu, Hongren, et al.
Publicado: (2013)

OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation
por: Dersh, Devin, et al.
Publicado: (2014)

Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems
por: Tekoah, Yoram, et al.
Publicado: (2013)

Acetaminophen Modulates the Transcriptional Response to Recombinant Interferon-β
por: Farnsworth, Aaron, et al.
Publicado: (2010)

Transgenic Overexpression of LARGE Induces α-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle
por: Brockington, Martin, et al.
Publicado: (2010)

Hyperglycosylated-hCG: Its Role in Trophoblast Invasion and Intrauterine Growth Restriction
por: Herghelegiu, Catalin Gabriel, et al.
Publicado: (2023)

Decreased expression of type I (IFN-β) and type III (IFN-λ) interferons and interferon-stimulated genes in patients with chronic rhinosinusitis with and without nasal polyps
por: Hwang, Jae Woong, et al.
Publicado: (2019)

The effects of interferon-β (IFN-β) treatment on synovial cytokine expression in collagen induced arthritis in DBA/1 mice
por: van Holten, J, et al.
Publicado: (2002)

Effect of interferon-γ (IFN-γ) on transforming growth factor-β (TGF-β) regulation of sialomucin complex/Muc4
por: Price-Schiavi, SA, et al.
Publicado: (2001)

TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor
por: Kim, Young-Woong, et al.
Publicado: (2012)

Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation
por: Zhang, Xiaolin, et al.
Publicado: (2018)

In silico design and analysis of a new hyperglycosylated analog of erythropoietin to improve drug efficacy
por: Kianmehr, Anvarsadat, et al.
Publicado: (2015)

Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties
por: Song, Kyoung, et al.
Publicado: (2014)

Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronaviruses
por: Dong, Xuefang, et al.
Publicado: (2022)

Enhancement of Cytotoxicity of Cisplatin in vitro by Recombinant Human Tumor Necrosis Factor and/or Recombinant Human Interferon‐α, β and ‐γ
por: Kim, Chang‐Min, et al.
Publicado: (1989)

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease
por: Mudò, Giuseppa, et al.
Publicado: (2019)

Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent Responses
por: Hwang, Mihyun, et al.
Publicado: (2018)

Migrating endothelial cells are distinctly hyperglycosylated and express specific migration-associated cell surface glycoproteins
Publicado: (1992)

Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β
por: Park, Jin Hee, et al.
Publicado: (2017)

Comparing the outcomes of treatment with INF-β 1-a (interferon beta-1a) and IFN-β 1-b (interferon beta-1b) among COVID-19 inpatients
por: Seyfi, Shahram, et al.
Publicado: (2021)

Interferon β-1a (IFNβ-1a) in COVID-19 patients (INTERCOP): study protocol for a randomized controlled trial
por: Bosi, Emanuele, et al.
Publicado: (2020)

Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy
por: Kim, Tae-Eun, et al.
Publicado: (2017)

Recombinant Interferon-β in the Treatment of Polycythemia Vera and Related Neoplasms: Rationales and Perspectives
por: Hasselbalch, Hans, et al.
Publicado: (2022)

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients
por: Hegen, Harald, et al.
Publicado: (2016)

IFN-β for the treatment of rheumatoid arthritis?
por: Tak, P, et al.
Publicado: (2003)

Targeted Recombinant Fusion Proteins of IFNγ and Mimetic IFNγ with PDGFβR Bicyclic Peptide Inhibits Liver Fibrogenesis In Vivo
por: Bansal, Ruchi, et al.
Publicado: (2014)

A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells
por: Tateno, Hiroaki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hn472hrcqpe0ddm93kffkbtutk