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Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen

Coronavirus disease 2019 or COVID-19 has rapidly emerged as a global pandemic. This viral infection involves the upper respiratory tract and could lead to severe pneumonia with respiratory distress or even death. Certain studies have found higher initial plasma levels of most pro-inflammatory cytoki...

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Autores principales: Gharebaghi, Reza, Heidary, Fatemeh, Moradi, Mohammad, Parvizi, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114714/
https://www.ncbi.nlm.nih.gov/pubmed/32259129
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author Gharebaghi, Reza
Heidary, Fatemeh
Moradi, Mohammad
Parvizi, Maryam
author_facet Gharebaghi, Reza
Heidary, Fatemeh
Moradi, Mohammad
Parvizi, Maryam
author_sort Gharebaghi, Reza
collection PubMed
description Coronavirus disease 2019 or COVID-19 has rapidly emerged as a global pandemic. This viral infection involves the upper respiratory tract and could lead to severe pneumonia with respiratory distress or even death. Certain studies have found higher initial plasma levels of most pro-inflammatory cytokines during the course of the infection. In this context, both in vitro and in vivo studies have revealed that metronidazole could decrease the levels of several cytokines, which are known to increase during the COVID-19 infection, including interleukin (IL)8, IL6, IL1B, tumor necrosis factor (TNF)α, IL12, IL1α, and interferon (IFN)γ, as well as the levels of C-reactive protein (CRP) and neutrophil count. Furthermore, the drug could decrease neutrophil-generated reactive oxygen species during inflammation. Metronidazole could counteract majority of the immunopathological manifestations of the COVID-19 infection. Therefore, studies with a large sample size are required to determine the efficacy of metronidazole in the treatment of COVID-19 infection.
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spelling pubmed-71147142020-04-03 Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen Gharebaghi, Reza Heidary, Fatemeh Moradi, Mohammad Parvizi, Maryam Arch Acad Emerg Med Commentary Coronavirus disease 2019 or COVID-19 has rapidly emerged as a global pandemic. This viral infection involves the upper respiratory tract and could lead to severe pneumonia with respiratory distress or even death. Certain studies have found higher initial plasma levels of most pro-inflammatory cytokines during the course of the infection. In this context, both in vitro and in vivo studies have revealed that metronidazole could decrease the levels of several cytokines, which are known to increase during the COVID-19 infection, including interleukin (IL)8, IL6, IL1B, tumor necrosis factor (TNF)α, IL12, IL1α, and interferon (IFN)γ, as well as the levels of C-reactive protein (CRP) and neutrophil count. Furthermore, the drug could decrease neutrophil-generated reactive oxygen species during inflammation. Metronidazole could counteract majority of the immunopathological manifestations of the COVID-19 infection. Therefore, studies with a large sample size are required to determine the efficacy of metronidazole in the treatment of COVID-19 infection. Shahid Beheshti University of Medical Sciences 2020-03-30 /pmc/articles/PMC7114714/ /pubmed/32259129 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Gharebaghi, Reza
Heidary, Fatemeh
Moradi, Mohammad
Parvizi, Maryam
Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen
title Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen
title_full Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen
title_fullStr Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen
title_full_unstemmed Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen
title_short Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen
title_sort metronidazole; a potential novel addition to the covid-19 treatment regimen
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114714/
https://www.ncbi.nlm.nih.gov/pubmed/32259129
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