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Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer

Exosomes are nanoscale phospholipid bilayer vesicles that can be artificially engineered into vectors for the treatment of cancer. Circular RNA (circRNA), a type of non-coding RNA, has crucial regulatory functions in various aspects of cancer, such as tumorigenesis, apoptosis, proliferation, invasio...

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Autores principales: Geng, Xiuchao, Lin, Xiaomeng, Zhang, Yuhao, Li, Qiang, Guo, Yajing, Fang, Chuan, Wang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114721/
https://www.ncbi.nlm.nih.gov/pubmed/32269609
http://dx.doi.org/10.3892/ol.2020.11449
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author Geng, Xiuchao
Lin, Xiaomeng
Zhang, Yuhao
Li, Qiang
Guo, Yajing
Fang, Chuan
Wang, Hong
author_facet Geng, Xiuchao
Lin, Xiaomeng
Zhang, Yuhao
Li, Qiang
Guo, Yajing
Fang, Chuan
Wang, Hong
author_sort Geng, Xiuchao
collection PubMed
description Exosomes are nanoscale phospholipid bilayer vesicles that can be artificially engineered into vectors for the treatment of cancer. Circular RNA (circRNA), a type of non-coding RNA, has crucial regulatory functions in various aspects of cancer, such as tumorigenesis, apoptosis, proliferation, invasion, metastasis and chemo- and radiotherapeutic resistance, as well as in cancer prognosis. Notably, the exosomal transfer of circRNAs may function to both promote and inhibit cancer. Numerous studies have addressed the importance of circRNAs in cancer and non-coding RNAs (such as microRNAs and long non-coding RNAs) in exosomes. However, little research has focussed on a class of RNAs called exosomal circRNAs. The present review discusses current studies regarding exosomal circRNAs, including their biogenesis and biological functions, their abundance in exosomes and possible sorting mechanisms and their potential roles in both promoting and inhibiting cancer. It is predicted that in the next five years there will be increasing research exploring the functional mechanisms of exosomal circRNA in various diseases, in particular their roles in cancer genesis and progression.
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spelling pubmed-71147212020-04-08 Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer Geng, Xiuchao Lin, Xiaomeng Zhang, Yuhao Li, Qiang Guo, Yajing Fang, Chuan Wang, Hong Oncol Lett Review Exosomes are nanoscale phospholipid bilayer vesicles that can be artificially engineered into vectors for the treatment of cancer. Circular RNA (circRNA), a type of non-coding RNA, has crucial regulatory functions in various aspects of cancer, such as tumorigenesis, apoptosis, proliferation, invasion, metastasis and chemo- and radiotherapeutic resistance, as well as in cancer prognosis. Notably, the exosomal transfer of circRNAs may function to both promote and inhibit cancer. Numerous studies have addressed the importance of circRNAs in cancer and non-coding RNAs (such as microRNAs and long non-coding RNAs) in exosomes. However, little research has focussed on a class of RNAs called exosomal circRNAs. The present review discusses current studies regarding exosomal circRNAs, including their biogenesis and biological functions, their abundance in exosomes and possible sorting mechanisms and their potential roles in both promoting and inhibiting cancer. It is predicted that in the next five years there will be increasing research exploring the functional mechanisms of exosomal circRNA in various diseases, in particular their roles in cancer genesis and progression. D.A. Spandidos 2020-05 2020-03-06 /pmc/articles/PMC7114721/ /pubmed/32269609 http://dx.doi.org/10.3892/ol.2020.11449 Text en Copyright: © Geng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Geng, Xiuchao
Lin, Xiaomeng
Zhang, Yuhao
Li, Qiang
Guo, Yajing
Fang, Chuan
Wang, Hong
Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer
title Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer
title_full Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer
title_fullStr Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer
title_full_unstemmed Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer
title_short Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer
title_sort exosomal circular rna sorting mechanisms and their function in promoting or inhibiting cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114721/
https://www.ncbi.nlm.nih.gov/pubmed/32269609
http://dx.doi.org/10.3892/ol.2020.11449
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