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Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer

BACKGROUND: In patients with epithelial ovarian cancer, whether metastasis to para-aortic lymph nodes located cephalad to the renal veins (supra-renal PAN) should be classified as regional lymph node metastasis or distant metastasis remains controversial. This study was a preliminary retrospective e...

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Autores principales: Komiyama, Shinichi, Nagashima, Masaru, Taniguchi, Tomoko, Rikitake, Takayuki, Morita, Mineto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114794/
https://www.ncbi.nlm.nih.gov/pubmed/32238145
http://dx.doi.org/10.1186/s12957-020-01841-8
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author Komiyama, Shinichi
Nagashima, Masaru
Taniguchi, Tomoko
Rikitake, Takayuki
Morita, Mineto
author_facet Komiyama, Shinichi
Nagashima, Masaru
Taniguchi, Tomoko
Rikitake, Takayuki
Morita, Mineto
author_sort Komiyama, Shinichi
collection PubMed
description BACKGROUND: In patients with epithelial ovarian cancer, whether metastasis to para-aortic lymph nodes located cephalad to the renal veins (supra-renal PAN) should be classified as regional lymph node metastasis or distant metastasis remains controversial. This study was a preliminary retrospective evaluation of the pattern of supra-renal PAN metastasis in patients with epithelial ovarian cancer. METHODS: The subjects were 25 patients with epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer who underwent systematic dissection of the para-aortic nodes, including the supra-renal PAN, and pelvic lymph nodes (PLN). Patient factors, perioperative factors, the number of dissected lymph nodes, and pathological lymph node metastasis were investigated. RESULTS: Supra-renal PAN metastasis was found in 4/25 patients (16.0%). None of the 14 patients with pT1 or pT2 disease had supra-renal PAN metastasis, while 4/11 patients (36.4%) with pT3 or ypT3 disease had such metastases. None of the patients had isolated supra-renal PAN metastasis, while patients with supra-renal PAN metastasis also had multiple metastases to the infra-renal PAN and PLN. CONCLUSIONS: In patients with epithelial ovarian cancer, supra-renal PAN metastases might be considered to be distant rather than regional metastases. Further studies are needed to better define the clinical significance of supra-renal PAN metastasis.
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spelling pubmed-71147942020-04-07 Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer Komiyama, Shinichi Nagashima, Masaru Taniguchi, Tomoko Rikitake, Takayuki Morita, Mineto World J Surg Oncol Research BACKGROUND: In patients with epithelial ovarian cancer, whether metastasis to para-aortic lymph nodes located cephalad to the renal veins (supra-renal PAN) should be classified as regional lymph node metastasis or distant metastasis remains controversial. This study was a preliminary retrospective evaluation of the pattern of supra-renal PAN metastasis in patients with epithelial ovarian cancer. METHODS: The subjects were 25 patients with epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer who underwent systematic dissection of the para-aortic nodes, including the supra-renal PAN, and pelvic lymph nodes (PLN). Patient factors, perioperative factors, the number of dissected lymph nodes, and pathological lymph node metastasis were investigated. RESULTS: Supra-renal PAN metastasis was found in 4/25 patients (16.0%). None of the 14 patients with pT1 or pT2 disease had supra-renal PAN metastasis, while 4/11 patients (36.4%) with pT3 or ypT3 disease had such metastases. None of the patients had isolated supra-renal PAN metastasis, while patients with supra-renal PAN metastasis also had multiple metastases to the infra-renal PAN and PLN. CONCLUSIONS: In patients with epithelial ovarian cancer, supra-renal PAN metastases might be considered to be distant rather than regional metastases. Further studies are needed to better define the clinical significance of supra-renal PAN metastasis. BioMed Central 2020-04-01 /pmc/articles/PMC7114794/ /pubmed/32238145 http://dx.doi.org/10.1186/s12957-020-01841-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Komiyama, Shinichi
Nagashima, Masaru
Taniguchi, Tomoko
Rikitake, Takayuki
Morita, Mineto
Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
title Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
title_full Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
title_fullStr Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
title_full_unstemmed Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
title_short Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
title_sort metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114794/
https://www.ncbi.nlm.nih.gov/pubmed/32238145
http://dx.doi.org/10.1186/s12957-020-01841-8
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