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Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment

[Image: see text] A phenotypic whole cell high-throughput screen against the asexual blood and liver stages of the malaria parasite identified a benzimidazole chemical series. Among the hits were the antiemetic benzimidazole drug Lerisetron 1 (IC(50) NF54 = 0.81 μM) and its methyl-substituted analog...

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Detalles Bibliográficos
Autores principales:	Mueller, Rudolf, Reddy, Virsinha, Nchinda, Aloysius T., Mebrahtu, Fanuel, Taylor, Dale, Lawrence, Nina, Tanner, Lloyd, Barnabe, Marine, Eyermann, Charles J., Zou, Bin, Kondreddi, Ravinder R., Lakshminarayana, Suresh B., Rottmann, Matthias, Street, Leslie J., Chibale, Kelly
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114883/ https://www.ncbi.nlm.nih.gov/pubmed/32258933 http://dx.doi.org/10.1021/acsomega.0c00327

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