Cargando…

Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness

Venous thromboembolism (VTE) is a common cardiovascular disease, for which several single nucleotide polymorphisms (SNPs) underlying susceptibility were identified. Apart from candidate gene approach, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associat...

Descripción completa

Detalles Bibliográficos
Autores principales: Tavares, Valéria, Pinto, Ricardo, Assis, Joana, Pereira, Deolinda, Medeiros, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114903/
https://www.ncbi.nlm.nih.gov/pubmed/32258274
http://dx.doi.org/10.1016/j.dib.2020.105399
_version_ 1783513985802305536
author Tavares, Valéria
Pinto, Ricardo
Assis, Joana
Pereira, Deolinda
Medeiros, Rui
author_facet Tavares, Valéria
Pinto, Ricardo
Assis, Joana
Pereira, Deolinda
Medeiros, Rui
author_sort Tavares, Valéria
collection PubMed
description Venous thromboembolism (VTE) is a common cardiovascular disease, for which several single nucleotide polymorphisms (SNPs) underlying susceptibility were identified. Apart from candidate gene approach, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associated SNPs, including some with no clear role in the haemostatic system. These genetic variants constitute potential cancer-related biomarkers, particularly predictive and prognostic biomarkers, as a two-way association between VTE and cancer is well established. The present dataset comprises the data obtained from GWAS performed to identify genetic variants associated with VTE risk. Furthermore, this dataset also comprises data regarding previously reported candidate gene and validation reports performed in adults of European ancestry that also analysed the VTE GWAS-identified variants. Lastly, to evaluate the impact of these genetic variants in carcinogenesis, a broad search was made, which has let us to establish putative links between several VTE-associated genes and cancer hallmarks in a review article entitled “Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: linkage to ovarian tumour behaviour”.
format Online
Article
Text
id pubmed-7114903
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-71149032020-04-06 Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness Tavares, Valéria Pinto, Ricardo Assis, Joana Pereira, Deolinda Medeiros, Rui Data Brief Biochemistry, Genetics and Molecular Biology Venous thromboembolism (VTE) is a common cardiovascular disease, for which several single nucleotide polymorphisms (SNPs) underlying susceptibility were identified. Apart from candidate gene approach, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associated SNPs, including some with no clear role in the haemostatic system. These genetic variants constitute potential cancer-related biomarkers, particularly predictive and prognostic biomarkers, as a two-way association between VTE and cancer is well established. The present dataset comprises the data obtained from GWAS performed to identify genetic variants associated with VTE risk. Furthermore, this dataset also comprises data regarding previously reported candidate gene and validation reports performed in adults of European ancestry that also analysed the VTE GWAS-identified variants. Lastly, to evaluate the impact of these genetic variants in carcinogenesis, a broad search was made, which has let us to establish putative links between several VTE-associated genes and cancer hallmarks in a review article entitled “Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: linkage to ovarian tumour behaviour”. Elsevier 2020-03-09 /pmc/articles/PMC7114903/ /pubmed/32258274 http://dx.doi.org/10.1016/j.dib.2020.105399 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Tavares, Valéria
Pinto, Ricardo
Assis, Joana
Pereira, Deolinda
Medeiros, Rui
Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
title Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
title_full Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
title_fullStr Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
title_full_unstemmed Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
title_short Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
title_sort dataset of gwas-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114903/
https://www.ncbi.nlm.nih.gov/pubmed/32258274
http://dx.doi.org/10.1016/j.dib.2020.105399
work_keys_str_mv AT tavaresvaleria datasetofgwasidentifiedvariantsunderlyingvenousthromboembolismsusceptibilityandlinkagetocanceraggressiveness
AT pintoricardo datasetofgwasidentifiedvariantsunderlyingvenousthromboembolismsusceptibilityandlinkagetocanceraggressiveness
AT assisjoana datasetofgwasidentifiedvariantsunderlyingvenousthromboembolismsusceptibilityandlinkagetocanceraggressiveness
AT pereiradeolinda datasetofgwasidentifiedvariantsunderlyingvenousthromboembolismsusceptibilityandlinkagetocanceraggressiveness
AT medeirosrui datasetofgwasidentifiedvariantsunderlyingvenousthromboembolismsusceptibilityandlinkagetocanceraggressiveness