Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance

Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above...

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Detalles Bibliográficos
Autores principales: Nikolich-Žugich, Janko, Lang, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114977/
http://dx.doi.org/10.1007/978-1-4020-9063-9_12
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author Nikolich-Žugich, Janko
Lang, Anna
author_facet Nikolich-Žugich, Janko
Lang, Anna
author_sort Nikolich-Žugich, Janko
collection PubMed
description Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above and beyond the changes seen in the aging of T-cell pool in the absence of TCE. This chapter discusses our current knowledge of the role of these expansions in health and disease, with a special focus on their influence upon immune defense against infectious diseases.
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spelling pubmed-71149772020-04-02 Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance Nikolich-Žugich, Janko Lang, Anna Handbook on Immunosenescence Article Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above and beyond the changes seen in the aging of T-cell pool in the absence of TCE. This chapter discusses our current knowledge of the role of these expansions in health and disease, with a special focus on their influence upon immune defense against infectious diseases. 2008-08-04 /pmc/articles/PMC7114977/ http://dx.doi.org/10.1007/978-1-4020-9063-9_12 Text en © Springer Science+Business Media B.V. 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Nikolich-Žugich, Janko
Lang, Anna
Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
title Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
title_full Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
title_fullStr Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
title_full_unstemmed Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
title_short Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
title_sort age-associated t-cell clonal expansions (tce) in vivo—implications for pathogen resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114977/
http://dx.doi.org/10.1007/978-1-4020-9063-9_12
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AT langanna ageassociatedtcellclonalexpansionstceinvivoimplicationsforpathogenresistance

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