Interferons and Their Use in Persistent Viral Infections

In 2007, the world celebrated the 50th anniversary of the discovery of interferon (IFN) by Isaacs and Lindenmann. Subsequently, the IFN-α gene was cloned, fully sequenced and IFN-α was produced in recombinant form. Recombinant IFN-α is now used as the basis for treatment of chronic hepatitis C virus...

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Autores principales: Chevaliez, Stéphane, Pawlotsky, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114994/
https://www.ncbi.nlm.nih.gov/pubmed/19048202
http://dx.doi.org/10.1007/978-3-540-79086-0_8
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author Chevaliez, Stéphane
Pawlotsky, Jean-Michel
author_facet Chevaliez, Stéphane
Pawlotsky, Jean-Michel
author_sort Chevaliez, Stéphane
collection PubMed
description In 2007, the world celebrated the 50th anniversary of the discovery of interferon (IFN) by Isaacs and Lindenmann. Subsequently, the IFN-α gene was cloned, fully sequenced and IFN-α was produced in recombinant form. Recombinant IFN-α is now used as the basis for treatment of chronic hepatitis C virus infection and can also be used to treat certain forms of chronic hepatitis B virus infections. IFNs have also been used in other viral infections, although with less success. The antiviral mechanisms of IFNs are reviewed in this chapter as well as the utility of IFNs in the treatment of persistent viral infections.
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spelling pubmed-71149942020-04-02 Interferons and Their Use in Persistent Viral Infections Chevaliez, Stéphane Pawlotsky, Jean-Michel Antiviral Strategies Article In 2007, the world celebrated the 50th anniversary of the discovery of interferon (IFN) by Isaacs and Lindenmann. Subsequently, the IFN-α gene was cloned, fully sequenced and IFN-α was produced in recombinant form. Recombinant IFN-α is now used as the basis for treatment of chronic hepatitis C virus infection and can also be used to treat certain forms of chronic hepatitis B virus infections. IFNs have also been used in other viral infections, although with less success. The antiviral mechanisms of IFNs are reviewed in this chapter as well as the utility of IFNs in the treatment of persistent viral infections. 2009 /pmc/articles/PMC7114994/ /pubmed/19048202 http://dx.doi.org/10.1007/978-3-540-79086-0_8 Text en © Springer-Verlag Berlin Heidelberg 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Chevaliez, Stéphane
Pawlotsky, Jean-Michel
Interferons and Their Use in Persistent Viral Infections
title Interferons and Their Use in Persistent Viral Infections
title_full Interferons and Their Use in Persistent Viral Infections
title_fullStr Interferons and Their Use in Persistent Viral Infections
title_full_unstemmed Interferons and Their Use in Persistent Viral Infections
title_short Interferons and Their Use in Persistent Viral Infections
title_sort interferons and their use in persistent viral infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114994/
https://www.ncbi.nlm.nih.gov/pubmed/19048202
http://dx.doi.org/10.1007/978-3-540-79086-0_8
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