RNA Interference Mechanisms and Therapeutic Applications

RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetic...

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Detalles Bibliográficos
Autores principales: Lamers, Anne E., de Kleijn, Dominique P. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115010/
http://dx.doi.org/10.1007/0-387-23329-6_7
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author Lamers, Anne E.
de Kleijn, Dominique P. V.
author_facet Lamers, Anne E.
de Kleijn, Dominique P. V.
author_sort Lamers, Anne E.
collection PubMed
description RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetics and therapeutic applications. We focus here on the aspects concerning RNAi mechanism, applications in mammals, and construct design and delivery. We summarize some therapeutic applications in general and speculate on the relevance in cardiovascular medicine.
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spelling pubmed-71150102020-04-02 RNA Interference Mechanisms and Therapeutic Applications Lamers, Anne E. de Kleijn, Dominique P. V. Cardiovascular Research Article RNA interference (RNAi) is a technology developed after the recent discovery of well-conserved cellular processes that induce posttranscriptional gene silencing triggered by small fragments of double-stranded RNA. This technique is rapidly developing into a promising tool used for functional genetics and therapeutic applications. We focus here on the aspects concerning RNAi mechanism, applications in mammals, and construct design and delivery. We summarize some therapeutic applications in general and speculate on the relevance in cardiovascular medicine. 2006 /pmc/articles/PMC7115010/ http://dx.doi.org/10.1007/0-387-23329-6_7 Text en © Springer Science+Business Media, Inc 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Lamers, Anne E.
de Kleijn, Dominique P. V.
RNA Interference Mechanisms and Therapeutic Applications
title RNA Interference Mechanisms and Therapeutic Applications
title_full RNA Interference Mechanisms and Therapeutic Applications
title_fullStr RNA Interference Mechanisms and Therapeutic Applications
title_full_unstemmed RNA Interference Mechanisms and Therapeutic Applications
title_short RNA Interference Mechanisms and Therapeutic Applications
title_sort rna interference mechanisms and therapeutic applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115010/
http://dx.doi.org/10.1007/0-387-23329-6_7
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