Vitamin B(12) is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

BACKGROUND: Bacterial meningitis (BM) causes apoptotic damage to the hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the cerebrospinal fluid of children. The Hcy pathway controls bioavailability of methyl, and its homeostasis can be modulated by vitamin B(12), a cofactor of t...

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Autores principales: de Queiroz, Karina Barbosa, Cavalcante-Silva, Vanessa, Lopes, Flávia Lombardi, Rocha, Gifone Aguiar, D’Almeida, Vânia, Coimbra, Roney Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115084/
https://www.ncbi.nlm.nih.gov/pubmed/32238192
http://dx.doi.org/10.1186/s12974-020-01763-y

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