Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease

OBJECTIVE: Glomerular injury is a prominent pathological feature of diabetic kidney disease (DKD). Constitutively active NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species that mediates hyperglycemia-induced mesangial cell (MC) fibrotic injury. However, the mechanism that Nox4 utili...

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Detalles Bibliográficos
Autores principales: Shi, Qian, Lee, Doug-Yoon, Féliers, Denis, Abboud, Hanna E., Bhat, Manzoor A., Gorin, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115155/
https://www.ncbi.nlm.nih.gov/pubmed/32240965
http://dx.doi.org/10.1016/j.molmet.2020.02.011

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