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The role of granulocyte colony-stimulating factor in breast cancer development: A review

Granulocyte-colony-stimulating factor (G-CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G-CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G-CSF (rhG-CSF) has been used to treat granulocytopenia and neu...

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Detalles Bibliográficos
Autores principales: Liu, Li, Liu, Yangyang, Yan, Xiaohua, Zhou, Chong, Xiong, Xiangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115204/
https://www.ncbi.nlm.nih.gov/pubmed/32186767
http://dx.doi.org/10.3892/mmr.2020.11017
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author Liu, Li
Liu, Yangyang
Yan, Xiaohua
Zhou, Chong
Xiong, Xiangyang
author_facet Liu, Li
Liu, Yangyang
Yan, Xiaohua
Zhou, Chong
Xiong, Xiangyang
author_sort Liu, Li
collection PubMed
description Granulocyte-colony-stimulating factor (G-CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G-CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G-CSF (rhG-CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G-CSF plays an important role in cancer progression. G-CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G-CSF has an adverse effect. The current review provides an overview of G-CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy.
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spelling pubmed-71152042020-04-08 The role of granulocyte colony-stimulating factor in breast cancer development: A review Liu, Li Liu, Yangyang Yan, Xiaohua Zhou, Chong Xiong, Xiangyang Mol Med Rep Articles Granulocyte-colony-stimulating factor (G-CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G-CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G-CSF (rhG-CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G-CSF plays an important role in cancer progression. G-CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G-CSF has an adverse effect. The current review provides an overview of G-CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy. D.A. Spandidos 2020-05 2020-03-10 /pmc/articles/PMC7115204/ /pubmed/32186767 http://dx.doi.org/10.3892/mmr.2020.11017 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Li
Liu, Yangyang
Yan, Xiaohua
Zhou, Chong
Xiong, Xiangyang
The role of granulocyte colony-stimulating factor in breast cancer development: A review
title The role of granulocyte colony-stimulating factor in breast cancer development: A review
title_full The role of granulocyte colony-stimulating factor in breast cancer development: A review
title_fullStr The role of granulocyte colony-stimulating factor in breast cancer development: A review
title_full_unstemmed The role of granulocyte colony-stimulating factor in breast cancer development: A review
title_short The role of granulocyte colony-stimulating factor in breast cancer development: A review
title_sort role of granulocyte colony-stimulating factor in breast cancer development: a review
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115204/
https://www.ncbi.nlm.nih.gov/pubmed/32186767
http://dx.doi.org/10.3892/mmr.2020.11017
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