Cargando…

β-asarone modulates Beclin-1, LC3 and p62 expression to attenuate Aβ(40) and Aβ(42) levels in APP/PS1 transgenic mice with Alzheimer's disease

Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly population. Autophagy is a well-known regulator of neurodegenerative diseases and β-asarone has been discovered to have certain neuropharmacological effects. Thus, the present study aimed to analyze the potential effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Minzhen, Huang, Liping, Zhong, Xiaoqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115210/ https://www.ncbi.nlm.nih.gov/pubmed/32186763 http://dx.doi.org/10.3892/mmr.2020.11026

Ejemplares similares

Neuroprotective Effects and Mechanism of β-Asarone against Aβ1–42-Induced Injury in Astrocytes
por: Yang, Yuanxiao, et al.
Publicado: (2017)

Beclin 1, LC3 and P62 Expression in Equine Sarcoids
por: Martano, Manuela, et al.
Publicado: (2021)

Effect of β-asarone in normal and β-amyloid-induced Alzheimeric rats
por: Saki, Golshid, et al.
Publicado: (2020)

Fate of β-asarone in Ayurvedic Sodhana process of Vacha
por: Gholkar, Manasi S., et al.
Publicado: (2013)

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40
por: Hu, Xiaoyan, et al.
Publicado: (2014)

Synergetic effect of β-asarone and cannabidiol against Aβ aggregation in vitro and in vivo
por: Duan, Fangyuan, et al.
Publicado: (2023)

α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy
por: Park, Sin-Hye, et al.
Publicado: (2017)

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio
por: Uemura, Kengo, et al.
Publicado: (2009)

Amyloid β-peptides 1–40 and 1–42 form oligomers with mixed β-sheets
por: Baldassarre, Maurizio, et al.
Publicado: (2017)

Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?
por: Klafki, Hans-Wolfgang, et al.
Publicado: (2022)

Nitro Derivatives of Naturally Occurring β-Asarone and Their Anticancer Activity
por: Shenvi, Suvarna, et al.
Publicado: (2014)

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40
por: Suire, Caitlin N., et al.
Publicado: (2020)

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease
por: Wang, Nanbu, et al.
Publicado: (2020)

Dynamic Blood Concentrations of Aβ(1–40) and Aβ(1–42) in Alzheimer’s Disease
por: Yang, Yuan-Han, et al.
Publicado: (2020)

CSF Aβ42 and Aβ42/Aβ40 Ratio in Alzheimer’s Disease and Frontotemporal Dementias
por: Constantinides, Vasilios C., et al.
Publicado: (2023)

β-Asarone Increases Chemosensitivity by Inhibiting Tumor Glycolysis in Gastric Cancer
por: Tao, Heyun, et al.
Publicado: (2020)

Aggregation States of Aβ(1–40), Aβ(1–42) and Aβp(3–42) Amyloid Beta Peptides: A SANS Study
por: Festa, Giulia, et al.
Publicado: (2019)

Distributions of Aβ42 and Aβ42/40 in the Cerebrospinal Fluid in View of the Probability Theory
por: Lewczuk, Piotr, et al.
Publicado: (2021)

Enhanced Aβ(1–40) Production in Endothelial Cells Stimulated with Fibrillar Aβ(1–42)
por: Rajadas, Jayakumar, et al.
Publicado: (2013)

Prognostic relevance of autophagy-related markers p62, LC3, and Beclin1 in ovarian cancer
por: Jovanović, Ljubiša, et al.
Publicado: (2022)

The Aβ1–42/Aβ1–40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1–42 alone
por: Delaby, Constance, et al.
Publicado: (2022)

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease
por: Janelidze, Shorena, et al.
Publicado: (2016)

β-Asarone Rescues Pb-Induced Impairments of Spatial Memory and Synaptogenesis in Rats
por: Yang, Qian-Qian, et al.
Publicado: (2016)

Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders
por: Balakrishnan, Rengasamy, et al.
Publicado: (2022)

Explore the Mechanism of β-Asarone on Improving Cognitive Dysfunction in Rats with Diabetic Encephalopathy
por: Cai, Jingwen, et al.
Publicado: (2022)

The Position of Aβ(22−40) and Aβ(1−42) in Anionic Lipid Membranes Containing Cholesterol
por: Barrett, Matthew A., et al.
Publicado: (2015)

Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE
por: Gao, Yuan, et al.
Publicado: (2023)

Dynamic Changes in the Levels of Amyloid-β(42) Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer’s Disease
por: Zhang, Liding, et al.
Publicado: (2021)

APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1
por: Chen, Yuzhi, et al.
Publicado: (2007)

Different Aggregation Pathways and Structures for Aβ40 and Aβ42 Peptides
por: Wang, Li, et al.
Publicado: (2021)

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
por: Michno, Wojciech, et al.
Publicado: (2019)

Combined Analysis of CSF Tau, Aβ42, Aβ1–42% and Aβ1–40(ox)% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia
por: Bibl, Mirko, et al.
Publicado: (2010)

Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice
por: Seabrook, Timothy J, et al.
Publicado: (2006)

A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics
por: Al- Ayadhi, Laila Y, et al.
Publicado: (2012)

The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer's Disease
por: Wang, Nanbu, et al.
Publicado: (2021)

Human platelets release amyloid peptides β(1-40) and β(1-42) in response to hemostatic, immune, and hypoxic stimuli
por: Wolska, Nina, et al.
Publicado: (2023)

Nonphosphorylated tau slows down Aβ(1–42) aggregation, binds to Aβ(1–42) oligomers, and reduces Aβ(1–42) toxicity
por: Beeg, Marten, et al.
Publicado: (2021)

Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia
por: Zhu, Xiaoyue, et al.
Publicado: (2022)

Cerebrospinal Fluid Aβ(42/40) Corresponds Better than Aβ(42) to Amyloid PET in Alzheimer’s Disease
por: Lewczuk, Piotr, et al.
Publicado: (2016)

P‐tau/Aβ42 and Aβ42/40 ratios in CSF are equally predictive of amyloid PET status
por: Campbell, Michelle R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_to0jnu4uq9k808mq2r9hm5591g