Mechano-genomic regulation of coronaviruses and its interplay with ageing

Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel i...

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Autores principales: Uhler, Caroline, Shivashankar, G. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115351/
https://www.ncbi.nlm.nih.gov/pubmed/32242128
http://dx.doi.org/10.1038/s41580-020-0242-z
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author Uhler, Caroline
Shivashankar, G. V.
author_facet Uhler, Caroline
Shivashankar, G. V.
author_sort Uhler, Caroline
collection PubMed
description Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.
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spelling pubmed-71153512020-04-02 Mechano-genomic regulation of coronaviruses and its interplay with ageing Uhler, Caroline Shivashankar, G. V. Nat Rev Mol Cell Biol Comment Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing. Nature Publishing Group UK 2020-04-02 2020 /pmc/articles/PMC7115351/ /pubmed/32242128 http://dx.doi.org/10.1038/s41580-020-0242-z Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Uhler, Caroline
Shivashankar, G. V.
Mechano-genomic regulation of coronaviruses and its interplay with ageing
title Mechano-genomic regulation of coronaviruses and its interplay with ageing
title_full Mechano-genomic regulation of coronaviruses and its interplay with ageing
title_fullStr Mechano-genomic regulation of coronaviruses and its interplay with ageing
title_full_unstemmed Mechano-genomic regulation of coronaviruses and its interplay with ageing
title_short Mechano-genomic regulation of coronaviruses and its interplay with ageing
title_sort mechano-genomic regulation of coronaviruses and its interplay with ageing
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115351/
https://www.ncbi.nlm.nih.gov/pubmed/32242128
http://dx.doi.org/10.1038/s41580-020-0242-z
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