Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease

Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluate...

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Detalles Bibliográficos
Autores principales: Belsher, Jon L., Gay, Peter, Brinton, Margo, DellaValla, Joseph, Ridenour, Robert, Lanciotti, Robert, Perelygin, Andrey, Zaki, Sherif, Paddock, Christopher, Querec, Troy, Zhu, Tuofu, Pulendran, Bali, Eidex, Rachel B., Hayes, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115366/
https://www.ncbi.nlm.nih.gov/pubmed/18023511
http://dx.doi.org/10.1016/j.vaccine.2007.08.061
Descripción
Sumario:Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.

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