Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

This work describes the design, synthesis, and evaluation of low-molecular weight peptidic SARS-CoV 3CL protease inhibitors. The inhibitors were designed based on the potent tripeptidic Z-Val-Leu-Ala(pyrrolidone-3-yl)-2-benzothiazole (8; K(i) = 4.1 nM), in which the P3 valine unit was substituted wi...

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Detalles Bibliográficos
Autores principales: Thanigaimalai, Pillaiyar, Konno, Sho, Yamamoto, Takehito, Koiwai, Yuji, Taguchi, Akihiro, Takayama, Kentaro, Yakushiji, Fumika, Akaji, Kenichi, Kiso, Yoshiaki, Kawasaki, Yuko, Chen, Shen-En, Naser-Tavakolian, Aurash, Schön, Arne, Freire, Ernesto, Hayashi, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115367/
https://www.ncbi.nlm.nih.gov/pubmed/23747811
http://dx.doi.org/10.1016/j.ejmech.2013.05.005

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