Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

Recently we identified cycloguanil-like dihydrotriazine derivatives, which provided host-factor directed antiviral activity against influenza viruses and respiratory syncytial virus (RSV), by targeting the human dihydrofolate reductase (hDHFR) enzyme. In this context we deemed interesting to further...

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Detalles Bibliográficos
Autores principales: Francesconi, Valeria, Giovannini, Luca, Santucci, Matteo, Cichero, Elena, Costi, Maria Paola, Naesens, Lieve, Giordanetto, Fabrizio, Tonelli, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115377/
https://www.ncbi.nlm.nih.gov/pubmed/29886325
http://dx.doi.org/10.1016/j.ejmech.2018.05.059

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