A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits

The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon α-2b (rIFNα-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this random...

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Autores principales: Gao, LuLu, Yu, Shouyi, Chen, Qing, Duan, Zhaojun, Zhou, Jie, Mao, Chen, Yu, Dexian, Zhu, Wenchang, Nie, Jun, Hou, Yunde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115383/
https://www.ncbi.nlm.nih.gov/pubmed/20394720
http://dx.doi.org/10.1016/j.vaccine.2010.03.062
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author Gao, LuLu
Yu, Shouyi
Chen, Qing
Duan, Zhaojun
Zhou, Jie
Mao, Chen
Yu, Dexian
Zhu, Wenchang
Nie, Jun
Hou, Yunde
author_facet Gao, LuLu
Yu, Shouyi
Chen, Qing
Duan, Zhaojun
Zhou, Jie
Mao, Chen
Yu, Dexian
Zhu, Wenchang
Nie, Jun
Hou, Yunde
author_sort Gao, LuLu
collection PubMed
description The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon α-2b (rIFNα-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFNα-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1–3 and adenovirus species B. However, no benefit was seen in preventing respiratory syncytial virus. No severe adverse events were reported. Therefore, the rIFNα-2b nasal spray was effective and well tolerated for preventing common viral respiratory infections in the military recruits.
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spelling pubmed-71153832020-04-02 A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits Gao, LuLu Yu, Shouyi Chen, Qing Duan, Zhaojun Zhou, Jie Mao, Chen Yu, Dexian Zhu, Wenchang Nie, Jun Hou, Yunde Vaccine Article The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon α-2b (rIFNα-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFNα-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1–3 and adenovirus species B. However, no benefit was seen in preventing respiratory syncytial virus. No severe adverse events were reported. Therefore, the rIFNα-2b nasal spray was effective and well tolerated for preventing common viral respiratory infections in the military recruits. Elsevier Ltd. 2010-06-17 2010-04-13 /pmc/articles/PMC7115383/ /pubmed/20394720 http://dx.doi.org/10.1016/j.vaccine.2010.03.062 Text en Copyright © 2010 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gao, LuLu
Yu, Shouyi
Chen, Qing
Duan, Zhaojun
Zhou, Jie
Mao, Chen
Yu, Dexian
Zhu, Wenchang
Nie, Jun
Hou, Yunde
A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
title A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
title_full A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
title_fullStr A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
title_full_unstemmed A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
title_short A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
title_sort randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115383/
https://www.ncbi.nlm.nih.gov/pubmed/20394720
http://dx.doi.org/10.1016/j.vaccine.2010.03.062
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