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A challenge to vaccinology: Living organisms trap information

Life couples reproduction of the cell machinery with replication of the genetic program. Both processes are linked to the expression of some information. Over time, reproduction can enhance the information of the machine. We show that accumulation of valuable information results from degradative pro...

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Detalles Bibliográficos
Autor principal: Danchin, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115390/
https://www.ncbi.nlm.nih.gov/pubmed/20006133
http://dx.doi.org/10.1016/j.vaccine.2009.10.071
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author Danchin, Antoine
author_facet Danchin, Antoine
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description Life couples reproduction of the cell machinery with replication of the genetic program. Both processes are linked to the expression of some information. Over time, reproduction can enhance the information of the machine. We show that accumulation of valuable information results from degradative processes required to make room for novel entities. Degradation systems act as Maxwell's demons, using energy not to make room per se, but to prevent degradation of what has some functional features. This myopic process will accumulate information, whatever its source, in a ratchet-like manner. The consequence is that genes acquired by horizontal transfer as well as viruses will tend to perpetuate in niches where they are functional, creating recurrent conditions for emergence of diseases.
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spelling pubmed-71153902020-04-02 A challenge to vaccinology: Living organisms trap information Danchin, Antoine Vaccine Article Life couples reproduction of the cell machinery with replication of the genetic program. Both processes are linked to the expression of some information. Over time, reproduction can enhance the information of the machine. We show that accumulation of valuable information results from degradative processes required to make room for novel entities. Degradation systems act as Maxwell's demons, using energy not to make room per se, but to prevent degradation of what has some functional features. This myopic process will accumulate information, whatever its source, in a ratchet-like manner. The consequence is that genes acquired by horizontal transfer as well as viruses will tend to perpetuate in niches where they are functional, creating recurrent conditions for emergence of diseases. Elsevier Ltd. 2009-12-30 2009-12-11 /pmc/articles/PMC7115390/ /pubmed/20006133 http://dx.doi.org/10.1016/j.vaccine.2009.10.071 Text en Copyright © 2009 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Danchin, Antoine
A challenge to vaccinology: Living organisms trap information
title A challenge to vaccinology: Living organisms trap information
title_full A challenge to vaccinology: Living organisms trap information
title_fullStr A challenge to vaccinology: Living organisms trap information
title_full_unstemmed A challenge to vaccinology: Living organisms trap information
title_short A challenge to vaccinology: Living organisms trap information
title_sort challenge to vaccinology: living organisms trap information
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115390/
https://www.ncbi.nlm.nih.gov/pubmed/20006133
http://dx.doi.org/10.1016/j.vaccine.2009.10.071
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