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Polyprotein cleavage mechanism of SARS CoV M(pro) and chemical modification of the octapeptide
The cleavage mechanism of severe acute respiratory syndrome (SARS) coronavirus main proteinase (M(pro) or 3CL(pro)) for the octapeptide AVLQSGFR is studied using molecular mechanics (MM) and quantum mechanics (QM). The catalytic dyad His-41 and Cys-145 in the active pocket between domain I and II se...
Autores principales: | Du, Qi-Shi, Wang, Shu-Qing, Zhu, Yu, Wei, Dong-Qing, Guo, Hong, Sirois, Suzanne, Chou, Kuo-Chen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115412/ https://www.ncbi.nlm.nih.gov/pubmed/15501516 http://dx.doi.org/10.1016/j.peptides.2004.06.018 |
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