Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties

The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural...

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Autores principales: Romero, M., Zanuy, M., Rosell, E., Cascante, M., Piulats, J., Font-Bardia, M., Balzarini, J., De Clerq, E., Pujol, M.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115430/
https://www.ncbi.nlm.nih.gov/pubmed/25481815
http://dx.doi.org/10.1016/j.ejmech.2014.11.060
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author Romero, M.
Zanuy, M.
Rosell, E.
Cascante, M.
Piulats, J.
Font-Bardia, M.
Balzarini, J.
De Clerq, E.
Pujol, M.D.
author_facet Romero, M.
Zanuy, M.
Rosell, E.
Cascante, M.
Piulats, J.
Font-Bardia, M.
Balzarini, J.
De Clerq, E.
Pujol, M.D.
author_sort Romero, M.
collection PubMed
description The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.
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spelling pubmed-71154302020-04-02 Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties Romero, M. Zanuy, M. Rosell, E. Cascante, M. Piulats, J. Font-Bardia, M. Balzarini, J. De Clerq, E. Pujol, M.D. Eur J Med Chem Original Article The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction. Elsevier Masson SAS. 2015-01-27 2014-12-01 /pmc/articles/PMC7115430/ /pubmed/25481815 http://dx.doi.org/10.1016/j.ejmech.2014.11.060 Text en Copyright © 2014 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Romero, M.
Zanuy, M.
Rosell, E.
Cascante, M.
Piulats, J.
Font-Bardia, M.
Balzarini, J.
De Clerq, E.
Pujol, M.D.
Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
title Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
title_full Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
title_fullStr Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
title_full_unstemmed Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
title_short Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
title_sort optimization of xanthatin extraction from xanthium spinosum l. and its cytotoxic, anti-angiogenesis and antiviral properties
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115430/
https://www.ncbi.nlm.nih.gov/pubmed/25481815
http://dx.doi.org/10.1016/j.ejmech.2014.11.060
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