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Hair cortisol in drug-naïve first-episode individuals with psychosis
OBJECTIVES: To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. METHODS: Twenty-four drug-naïve FEP patients and 27 gender- and age-matched healthy control subject...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Psiquiatria
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115472/ https://www.ncbi.nlm.nih.gov/pubmed/26814837 http://dx.doi.org/10.1590/1516-4446-2014-1634 |
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author | Andrade, Elvis H. Rizzo, Lucas B. Noto, Cristiano Ota, Vanessa K. Gadelha, Ary Daruy-Filho, Ledo Tasso, Brazílio de C. Mansur, Rodrigo B. Cordeiro, Quirino Belangero, Síntia I. Bressan, Rodrigo A. Grassi-Oliveira, Rodrigo Brietzke, Elisa |
author_facet | Andrade, Elvis H. Rizzo, Lucas B. Noto, Cristiano Ota, Vanessa K. Gadelha, Ary Daruy-Filho, Ledo Tasso, Brazílio de C. Mansur, Rodrigo B. Cordeiro, Quirino Belangero, Síntia I. Bressan, Rodrigo A. Grassi-Oliveira, Rodrigo Brietzke, Elisa |
author_sort | Andrade, Elvis H. |
collection | PubMed |
description | OBJECTIVES: To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. METHODS: Twenty-four drug-naïve FEP patients and 27 gender- and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp: segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol. RESULTS: Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F(1.106) = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score. CONCLUSIONS: Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission. |
format | Online Article Text |
id | pubmed-7115472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Associação Brasileira de Psiquiatria |
record_format | MEDLINE/PubMed |
spelling | pubmed-71154722020-04-03 Hair cortisol in drug-naïve first-episode individuals with psychosis Andrade, Elvis H. Rizzo, Lucas B. Noto, Cristiano Ota, Vanessa K. Gadelha, Ary Daruy-Filho, Ledo Tasso, Brazílio de C. Mansur, Rodrigo B. Cordeiro, Quirino Belangero, Síntia I. Bressan, Rodrigo A. Grassi-Oliveira, Rodrigo Brietzke, Elisa Braz J Psychiatry Original Article OBJECTIVES: To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. METHODS: Twenty-four drug-naïve FEP patients and 27 gender- and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp: segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol. RESULTS: Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F(1.106) = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score. CONCLUSIONS: Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission. Associação Brasileira de Psiquiatria 2016-01-26 /pmc/articles/PMC7115472/ /pubmed/26814837 http://dx.doi.org/10.1590/1516-4446-2014-1634 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Andrade, Elvis H. Rizzo, Lucas B. Noto, Cristiano Ota, Vanessa K. Gadelha, Ary Daruy-Filho, Ledo Tasso, Brazílio de C. Mansur, Rodrigo B. Cordeiro, Quirino Belangero, Síntia I. Bressan, Rodrigo A. Grassi-Oliveira, Rodrigo Brietzke, Elisa Hair cortisol in drug-naïve first-episode individuals with psychosis |
title | Hair cortisol in drug-naïve first-episode individuals with psychosis |
title_full | Hair cortisol in drug-naïve first-episode individuals with psychosis |
title_fullStr | Hair cortisol in drug-naïve first-episode individuals with psychosis |
title_full_unstemmed | Hair cortisol in drug-naïve first-episode individuals with psychosis |
title_short | Hair cortisol in drug-naïve first-episode individuals with psychosis |
title_sort | hair cortisol in drug-naïve first-episode individuals with psychosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115472/ https://www.ncbi.nlm.nih.gov/pubmed/26814837 http://dx.doi.org/10.1590/1516-4446-2014-1634 |
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