Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

Coronaviral infection is associated with up to 5% of respiratory tract diseases. The 3C-like protease (3CL(pro)) of coronaviruses is required for proteolytic processing of polyproteins and viral replication, and is a promising target for the development of drugs against coronaviral infection. We des...

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Detalles Bibliográficos
Autores principales: Chuck, Chi-Pang, Chen, Chao, Ke, Zhihai, Chi-Cheong Wan, David, Chow, Hak-Fun, Wong, Kam-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115530/
https://www.ncbi.nlm.nih.gov/pubmed/23202846
http://dx.doi.org/10.1016/j.ejmech.2012.10.053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115530/
https://www.ncbi.nlm.nih.gov/pubmed/23202846
http://dx.doi.org/10.1016/j.ejmech.2012.10.053

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